Sarcopenia and smoking: a possible cellular model of cigarette smoke effects on muscle protein breakdown
Article first published online: 3 JUL 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1259, Environmental Stressors in Biology and Medicine pages 47–53, July 2012
How to Cite
Rom, O., Kaisari, S., Aizenbud, D. and Reznick, A. Z. (2012), Sarcopenia and smoking: a possible cellular model of cigarette smoke effects on muscle protein breakdown. Annals of the New York Academy of Sciences, 1259: 47–53. doi: 10.1111/j.1749-6632.2012.06532.x
- Issue published online: 3 JUL 2012
- Article first published online: 3 JUL 2012
- cigarette smoke;
Sarcopenia, the age-related loss of muscle mass and strength, is a multifactorial impaired state of health. Lifestyle habits such as physical activity and nutrition have a major impact on sarcopenia progression. Several epidemiological studies have also shown an association between cigarette smoking and increased levels of sarcopenia in elderly long-time smokers. Clinical, in vivo, and in vitro studies have tried to investigate the mechanism behind exposure to cigarette smoke (CS) and the subsequent effects on skeletal muscles. The aim of this review is to present a cellular model of CS-induced skeletal muscle protein breakdown based on recent studies dealing with this issue and to propose new potential research directions that may explain the effects of exposure to CS on skeletal muscle integrity.