The protozoan pathogen Toxoplasma gondii targets the paracellular pathway to invade the intestinal epithelium
Article first published online: 25 JUN 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1258, Barriers and Channels Formed by Tight Junction Proteins II pages 135–142, July 2012
How to Cite
Weight, C. M. and Carding, S. R. (2012), The protozoan pathogen Toxoplasma gondii targets the paracellular pathway to invade the intestinal epithelium. Annals of the New York Academy of Sciences, 1258: 135–142. doi: 10.1111/j.1749-6632.2012.06534.x
- Issue published online: 25 JUN 2012
- Article first published online: 25 JUN 2012
- Toxoplasma gondii;
- tight junctions;
Abstract Toxoplasma gondii is a ubiquitous parasite found within all mammals and birds worldwide that can cause fatal infections in immunocompromised persons and fetuses. The parasite causes chronic infections by residing in long-living tissues of the muscle and brain. T. gondii infects the host through contaminated meat and water consumption with the gastrointestinal tract (GI tract) being the first point of contact with the host. The mechanisms by which the parasite invades the host through the GI tract are unknown, although it has been suggested that the paracellular pathway is important for parasite dissemination. Studies indicate that epithelial tight junction–associated proteins are affected by T. gondii, although which junctional proteins are affected and the nature of host protein–parasite interactions have not been established. We have uncovered evidence that T. gondii influences the cellular distribution of occludin to transmigrate the intestinal epithelium and suggest how candidate binding partners can be identified.