Analysis of absorption enhancers in epithelial cell models
Article first published online: 25 JUN 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1258, Barriers and Channels Formed by Tight Junction Proteins II pages 86–92, July 2012
How to Cite
Rosenthal, R., Heydt, M. S., Amasheh, M., Stein, C., Fromm, M. and Amasheh, S. (2012), Analysis of absorption enhancers in epithelial cell models. Annals of the New York Academy of Sciences, 1258: 86–92. doi: 10.1111/j.1749-6632.2012.06562.x
- Issue published online: 25 JUN 2012
- Article first published online: 25 JUN 2012
- tight junctions;
A variety of chemical compounds are currently being discussed as novel drug delivery strategies. One promising strategy is to selectively open the paracellular pathway of epithelia for the passage of macromolecules. A prerequisite for this effect is a rapid and reversible action of these compounds, to allow a marked translocation of a drug, but also to avoid unwanted adverse effects, such as the translocation of noxious agents. Bioactive molecules that elevate paracellular permeability include Ca2+ chelators, bacterial toxins, and other compounds, some of which perturb the structural basis of epithelial barrier function—the tight junction. Within the tight junction, organ- and tissue-specific barrier properties are determined mainly by claudins. The majority of members of the claudin protein family seal the paracellular pathway. This paper focuses on recent approaches concerning absorption-enhancing effects, with regard to selectivity and mechanism.