Claudin-based paracellular proton barrier in the stomach
Article first published online: 25 JUN 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1258, Barriers and Channels Formed by Tight Junction Proteins II pages 108–114, July 2012
How to Cite
Tamura, A., Yamazaki, Y., Hayashi, D., Suzuki, K., Sentani, K., Yasui, W. and Tsukita, S. (2012), Claudin-based paracellular proton barrier in the stomach. Annals of the New York Academy of Sciences, 1258: 108–114. doi: 10.1111/j.1749-6632.2012.06570.x
- Issue published online: 25 JUN 2012
- Article first published online: 25 JUN 2012
- proton barrier;
- knockout mouse;
The claudins comprise a multigene family that consists of at least 27 members. Claudins are responsible for establishing the paracellular barrier—which has permselectivity—at the tight junctions in epithelial cells, and the specific patterns of claudin expression in the epithelial cell sheets that cover the internal and external surfaces of organs contribute to the formation of microenvironments and organs’ biological functions. Data on the detailed characterization of individual claudins and their roles in different microenvironments are accumulating. A study on the stomach-specific claudin-18–knockout mouse, which has gastritis, recently revealed that the stomach-type claudin-18 specifically forms the proton barrier in the stomach, consistent with previously reported circumstantial evidence. Combined with previous studies on the specific ionic homeostasis by different types of claudins, our findings support the idea that claudins may regulate ion-specific homeostasis in vivo.