Cigarette smoke and ozone effect on murine inflammatory responses
Article first published online: 3 JUL 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1259, Environmental Stressors in Biology and Medicine pages 104–111, July 2012
How to Cite
Gardi, C. and Valacchi, G. (2012), Cigarette smoke and ozone effect on murine inflammatory responses. Annals of the New York Academy of Sciences, 1259: 104–111. doi: 10.1111/j.1749-6632.2012.06605.x
- Issue published online: 3 JUL 2012
- Article first published online: 3 JUL 2012
- mouse models;
- lung injury;
- air pollution;
- oxidative stress
Air pollution has been associated with many different diseases, such as cancer, and respiratory, cardiovascular, and cutaneous chronic diseases. These effects are enhanced in people exposed to combined air pollutants, such as ozone and cigarette smoke. Chronic exposure to these pollutants causes an increase in oxidative stress and inflammation and has been associated with an increase in pulmonary diseases and mortality. Clinical and epidemiological studies reported interindividual variability in the adverse health effects of air pollutants, suggesting a genetic predisposition. The identification of subgroups of the population who are particularly vulnerable to air pollution is, therefore, of importance. Mouse models are a useful tool for studying the mechanisms underlying different susceptibility, as they show differences in strain responses to both ozone and cigarette smoke. This review analyses the role of inflammation and the influence of genetic factors on the mechanisms of lung injury caused by ozone and cigarette smoke.