Aging and the neurovascular unit
Article first published online: 20 SEP 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1268, Thrombolysis and Acute Stroke Treatment pages 127–133, September 2012
How to Cite
del Zoppo, G. J. (2012), Aging and the neurovascular unit. Annals of the New York Academy of Sciences, 1268: 127–133. doi: 10.1111/j.1749-6632.2012.06686.x
- Issue published online: 20 SEP 2012
- Article first published online: 20 SEP 2012
- amyloid deposition;
- ischemic stroke;
- permeability barriers;
- neurovascular unit
With the demonstration that acute recanalization of obstructed symptomatic cerebral arteries during ischemic stroke can result in substantial improvement in clinical outcome, the variability in clinical responses, and in hemorrhagic transformation, requires attention. This short review addresses the effect of aging and amyloid deposition disease on microvessel integrity, interactions within the neurovascular unit, cerebral tissue susceptibility to ischemic injury, and postischemic inflammation, and ultimately on the outcomes and safety of acute recanalization during ischemic stroke. Microvessels and neighboring neurons respond simultaneously to focal ischemia. The cellular components and matrix barriers of the neurovascular unit all respond to ischemia; however, their coordinate interactions are not understood. Furthermore, there is little known about the cell–cell and cell–matrix interactions within the unit, or about the effect of β-amyloid on microvessel responses during ischemia. These considerations indicate the need for a coordinated research effort to understand the origins of the variability in recanalization outcome.