These authors equally contributed to the manuscript.
Cutaneous responses to environmental stressors
Article first published online: 10 OCT 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1271, Nutrition and Physical Activity in Aging, Obesity, and Cancer pages 75–81, October 2012
How to Cite
Valacchi, G., Sticozzi, C., Pecorelli, A., Cervellati, F., Cervellati, C. and Maioli, E. (2012), Cutaneous responses to environmental stressors. Annals of the New York Academy of Sciences, 1271: 75–81. doi: 10.1111/j.1749-6632.2012.06724.x
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- Issue published online: 10 OCT 2012
- Article first published online: 10 OCT 2012
- cigarette smoke;
Living organisms are continuously exposed to environmental pollutants. Because of its critical location, the skin is a major interface between the body and the environment and provides a biological barrier against an array of chemical and physical environmental pollutants. The skin can be defined as our first defense against the environment because of its constant exposure to oxidants, including ultraviolet (UV) radiation and other environmental pollutants such as diesel fuel exhaust, cigarette smoke (CS), halogenated hydrocarbons, heavy metals, and ozone (O3). The exposure to environmental pro-oxidant agents leads to the formation of reactive oxygen species (ROS) and the generation of bioactive molecules that can damage skin cells. This short review provides an overview of the effects and mechanisms of action of CS, O3, and UV on cutanous tissues.