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Genomics of complex traits
Article first published online: 10 OCT 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1271, Nutrition and Physical Activity in Aging, Obesity, and Cancer pages 33–36, October 2012
How to Cite
Womack, J. E., Jang, H.-J. and Lee, M. O. (2012), Genomics of complex traits. Annals of the New York Academy of Sciences, 1271: 33–36. doi: 10.1111/j.1749-6632.2012.06733.x
- Issue published online: 10 OCT 2012
- Article first published online: 10 OCT 2012
- complex traits;
- animals, disease resistance;
The analysis of complex genetic traits, including mapping and identification of causative genes, has long been an enigma of genetic biology, whether in the animal sciences or in medical sciences. Traits of agricultural interest and traits of medical interest are often under the influence of both environmental factors and multiple genes, each with modest contributions to the total variance in the trait. Although the number of known mutations underlying complex traits is still relatively small, advances in genomics have greatly enhanced traditional pathways to their analysis and gene mining. The candidate gene approach, linkage analysis, and association studies are all significantly more powerful with recent advances in genome mapping, sequencing, and analysis of individual variation. Avenues to gene discovery are discussed with emphasis on genome wide association studies (GWAS) and the use of single nucleotide polymorphisms (SNPs) as revealed by increasingly powerful commercially available microarrays.