Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms
Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression
Article first published online: 10 OCT 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1271, Nutrition and Physical Activity in Aging, Obesity, and Cancer pages 44–52, October 2012
How to Cite
Wang, H.-C., Pao, J., Lin, S.-Y. and Sheen, L.-Y. (2012), Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression. Annals of the New York Academy of Sciences, 1271: 44–52. doi: 10.1111/j.1749-6632.2012.06743.x
- Issue published online: 10 OCT 2012
- Article first published online: 10 OCT 2012
- allyl sulfides;
- ER stress;
- skin cancer
Skin cancer is a serious concern whose incidence is increasing at an alarming rate. Allyl sulfides—i.e., sulfur metabolites in garlic oil—have been demonstrated to have anticancer activity against several cancer types, although the mechanisms underlying these effects remain enigmatic. Our previous study showed that diallyl trisulfide (DATS) is more potent than mono- and disulfides against skin cancer. DATS inhibits cell growth of human melanoma A375 cells and basal cell carcinoma (BCC) cells by increasing the levels of intracellular reactive oxygen species (ROS) and DNA damage and by inducing G2/M arrest, endoplasmic reticulum (ER) stress, and mitochondria-mediated apoptosis, including the caspase-dependent and -independent pathways. This short review focuses on the molecular mechanisms of garlic-derived allyl sulfides on skin cancer prevention.