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Janus-faced role of SIRT1 in tumorigenesis
Version of Record online: 10 OCT 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1271, Nutrition and Physical Activity in Aging, Obesity, and Cancer pages 10–19, October 2012
How to Cite
Song, N.-Y. and Surh, Y.-J. (2012), Janus-faced role of SIRT1 in tumorigenesis. Annals of the New York Academy of Sciences, 1271: 10–19. doi: 10.1111/j.1749-6632.2012.06762.x
- Issue online: 10 OCT 2012
- Version of Record online: 10 OCT 2012
- subcellular localization
Silent mating type information regulation 1 (Sirtuin 1; SIRT1) has been reported to regulate various physiological events, such as aging and metabolism, via deacetylation of histone and nonhistone proteins. Notably, cumulative evidence supports the notion that SIRT1 has a Janus-faced role in tumorigenesis. SIRT1 contributes to anti-inflammation, genomic stability, and cancer cell death, and hence it has tumor-suppressor properties. On the other hand, SIRT1 can stimulate oncogenic signaling pathways and can create a tumor microenvironment favorable to growth and survival of cancer cells. Such dual functions of SIRT1 may be determined, at least in part, by its subcellular localization. Interestingly, SIRT1 displays differential localization in normal cells and cancer cells, which in turn may affect the substrate specificity for its deacetylase activity.