• Open Access

Janus-faced role of SIRT1 in tumorigenesis

Authors

  • Na-Young Song,

    1. Tumor Microenvironment Global Core Research Center, College of Pharmacy
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  • Young-Joon Surh

    1. Tumor Microenvironment Global Core Research Center, College of Pharmacy
    2. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Sciences and Technology
    3. Cancer Research Institute, Seoul National University, Seoul, South Korea
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Young-Joon Surh, Ph.D., College of Pharmacy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, South Korea. surh@plaza.snu.ac.kr

Abstract

Silent mating type information regulation 1 (Sirtuin 1; SIRT1) has been reported to regulate various physiological events, such as aging and metabolism, via deacetylation of histone and nonhistone proteins. Notably, cumulative evidence supports the notion that SIRT1 has a Janus-faced role in tumorigenesis. SIRT1 contributes to anti-inflammation, genomic stability, and cancer cell death, and hence it has tumor-suppressor properties. On the other hand, SIRT1 can stimulate oncogenic signaling pathways and can create a tumor microenvironment favorable to growth and survival of cancer cells. Such dual functions of SIRT1 may be determined, at least in part, by its subcellular localization. Interestingly, SIRT1 displays differential localization in normal cells and cancer cells, which in turn may affect the substrate specificity for its deacetylase activity.

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