The physiology of bacterial cell division
Article first published online: 5 DEC 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1277, Antimicrobial Therapeutics Reviews pages 8–28, January 2013
How to Cite
Egan, A. J. F. and Vollmer, W. (2013), The physiology of bacterial cell division. Annals of the New York Academy of Sciences, 1277: 8–28. doi: 10.1111/j.1749-6632.2012.06818.x
- Issue published online: 24 JAN 2013
- Article first published online: 5 DEC 2012
- cell division;
- penicillin-binding protein;
- peptidoglycan hydrolyase;
- outer membrane;
Bacterial cell division is facilitated by the divisome, a dynamic multiprotein assembly localizing at mid-cell to synthesize the stress-bearing peptidoglycan and to constrict all cell envelope layers. Divisome assembly occurs in two steps and involves multiple interactions between more than 20 essential and accessory cell division proteins. Well before constriction and while the cell is still elongating, the tubulin-like FtsZ and early cell division proteins form a ring-like structure at mid-cell. Cell division starts once certain peptidoglycan enzymes and their activators have moved to the FtsZ-ring. Gram-negative bacteria like Escherichia coli simultaneously synthesize and cleave the septum peptidoglycan during division leading to a constriction. The outer membrane constricts together with the peptidoglycan layer with the help of the transenvelope spanning Tol–Pal system.