Deep brain stimulation of the nucleus accumbens for the treatment of addiction
Article first published online: 10 DEC 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1282, Addiction Reviews pages 119–128, April 2013
How to Cite
Müller, U. J., Voges, J., Steiner, J., Galazky, I., Heinze, H.-J., Möller, M., Pisapia, J., Halpern, C., Caplan, A., Bogerts, B. and Kuhn, J. (2013), Deep brain stimulation of the nucleus accumbens for the treatment of addiction. Annals of the New York Academy of Sciences, 1282: 119–128. doi: 10.1111/j.1749-6632.2012.06834.x
- Issue published online: 2 APR 2013
- Article first published online: 10 DEC 2012
- deep brain stimulation;
- nucleus accumbens;
Despite novel medications and other therapeutic strategies, addiction to psychotropic substances remains one of the most serious public health problems worldwide. In this review, beginning with an introduction of deep brain stimulation (DBS), we highlight the importance of the nucleus accumbens (NAc) in the context of the reward circuitry and addictive behavior. We will provide a short historic overview of other neurosurgical approaches to treat addiction and describe the experimental and preclinical data on DBS in addiction. Finally, we call attention to key ethical issues related to using DBS to treat addiction that are important for future research and the design of clinical trials.