Sexual dimorphism in lung function responses to acute influenza A infection
Version of Record online: 21 MAR 2011
© 2011 Blackwell Publishing Ltd
Influenza and Other Respiratory Viruses
Volume 5, Issue 5, pages 334–342, September 2011
How to Cite
Larcombe, A. N., Foong, R. E., Bozanich, E. M., Berry, L. J., Garratt, L. W., Gualano, R. C., Jones, J. E., Dousha, L. F., Zosky, G. R. and Sly, P. D. (2011), Sexual dimorphism in lung function responses to acute influenza A infection. Influenza and Other Respiratory Viruses, 5: 334–342. doi: 10.1111/j.1750-2659.2011.00236.x
- Issue online: 10 AUG 2011
- Version of Record online: 21 MAR 2011
- Accepted 4 February 2011. Published Online 21 March 2011.
- Airway responsiveness;
- cellular inflammation;
- sexual dimorphism
Please cite this paper as: Larcombe et al. (2011) Sexual dimorphism in lung function responses to acute influenza A infection. Influenza and Other Respiratory Viruses 5(5), 334–342.
Background Males are generally more susceptible to respiratory infections; however, there are few data on the physiological responses to such infections in males and females.
Objectives To determine whether sexual dimorphism exists in the physiological/inflammatory responses of weanling and adult BALB/c mice to influenza.
Methods Weanling and adult mice of both sexes were inoculated with influenza A or appropriate control solution. Respiratory mechanics, responsiveness to methacholine (MCh), viral titre and bronchoalveolar lavage (BAL) cellular inflammation/cytokines were measured 4 (acute) and 21 (resolution) days post-inoculation.
Results Acute infection impaired lung function and induced hyperresponsiveness and cellular inflammation in both sexes at both ages. Males and females responded differently with female mice developing greater abnormalities in tissue damping and elastance and greater MCh responsiveness at both ages. BAL inflammation, cytokines and lung viral titres were similar between the sexes. At resolution, all parameters had returned to baseline levels in adults and weanling males; however, female weanlings had persisting hyperresponsiveness.
Conclusions We identified significant differences in the physiological responses of male and female mice to infection with influenza A, which occurred in the absence of variation in viral titre and cellular inflammation.