Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study
Article first published online: 26 NOV 2011
© 2011 Blackwell Publishing Ltd
Influenza and Other Respiratory Viruses
Volume 6, Issue 4, pages 299–303, July 2012
How to Cite
Higa, F., Tateyama, M., Tomishima, M., Mukatake, S., Yamashiro, T., Owan, T., Haranaga, S. and Fujita, J. (2012), Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study. Influenza and Other Respiratory Viruses, 6: 299–303. doi: 10.1111/j.1750-2659.2011.00311.x
- Issue published online: 7 JUN 2012
- Article first published online: 26 NOV 2011
- Accepted 9 October 2011. Published Online 25 November 2011.
- infection control;
- neuraminidase inhibitor
Please cite this paper as: Higa et al. (2012) Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study. Influenza and Other Respiratory Viruses 6(4), 299–303.
Background An influenza outbreak might result in disruption of services at acute care setting hospitals.
Objectives In this study, we retrospectively evaluated the use of neuraminidase inhibitor chemoprophylaxis for prevention of nosocomial spread of influenza in a university hospital.
Patients/Methods During the 3-year study period, 202 index cases of influenza [30 hospitalized patients and 172 healthcare workers (HCW)] and 762 individuals who had had close contact with the index cases (248 hospitalized patients and 514 HCW) were identified. Of these contacts, 416 received neuraminidase inhibitor chemoprophylaxis.
Results When both the index cases and the close contacts were hospitalized patients, the incidence of influenza was lower among the close contacts who received chemoprophylaxis than among those who did not (odds ratio, 0·07; confidence interval, 0·01–0·49; P = 0·012). In contrast, when the index cases were HCW, the incidence of influenza was not different between close contacts who did or did not receive chemoprophylaxis.
Conclusions This study suggests that chemoprophylaxis might be useful to prevent nosocomial spread of infection between hospitalized patients.