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Epidemiological aspects of pandemic influenza A(H1N1) virus from 2009 to 2011 in Iran

Authors


Talat Mokhtari. Azad, Porsina Ave, Keshavarz Blv, PO 14155-6446, Tehran, Iran. E-mail: mokhtari@sina.tums.ac.ir

Abstract

Please cite this paper as: Yavarian et al. (2012). Epidemiological aspects of pandemic influenza A(H1N1) virus from 2009 to 2011 in Iran. Influenza and Other Respiratory Viruses 6(601), e74–e76.

To the editor:

As the world was preparing for a pandemic influenza of avian origin, in April 2009 a novel influenza A virus H1N1 strain of swine origin, now known as pandemic A(H1N1) 2009 virus (abbreviated as pH1N1), emerged in Mexico and spread quickly worldwide.1–3 On April 24, 2009, the World Health Organization announced a Public Health Emergency of International Concern caused by this new influenza virus variant.4 Approximately 8 weeks later on June 20, 2009, the first case of pH1N1 in Iran was reported in a traveler from the United States.

Following the detection of the first imported confirmed pH1N1 infection in Iran, the National Influenza Center in collaboration with the Ministry of Health enhanced surveillance for pH1N1 virus infection in addition to the existing sentinel surveillance system for seasonal influenza and imposed entry screening on travelers from affected areas. Specimens were collected for laboratory testing from suspected cases with influenza-like illness (ILI) symptoms, fever with history of recent traveling, or having a contact with a confirmed case of pH1N1.

The population of Iran is around 75 million. This letter reports the available epidemiological characteristics of 40 169 suspected cases of pH1N1 infection between June 20, 2009 and November 21, 2011.

During July through September 2009, Iran experienced some transmission of pH1N1; a stronger wave began in October, and a peak occurred in November and then declined steadily. There was a small second wave in early 2011. Among the total of 40 169 suspected cases, 5214 (12·9%) were confirmed cases with real-time RT-PCR (using the Invitrogen SuperScript III Platinum with specific primers obtained from the United States Centers for Disease Control and Prevention real time RT-PCR Protocol5) of whom 230 (4·4%) were classified as imported, travel-associated cases.

As shown in Figure 1, the highest incidence of confirmed cases occurred in October and November 2009, after schools had reopened in September. School children are known to be important in transmission of influenza. During this outbreak, an increase in the number of absenteeism owing to ILI symptoms led schools to close in some parts of the country especially in the central and south-east regions of Iran.

Figure 1.

 Number of laboratory confirmed cases of 2009 pandemic A(H1N1) virus infection, by month in Iran, 20 June 2009–21 November 2011.

The greatest number of confirmed cases occurred in the age group of 20–49 years, accounting for 2710 (51·9%) of all confirmed cases, followed by 919 (17·6%) in children aged 5–14 years and the lowest number was in elderly aged 65 years and older, with 159 (3%) confirmed cases. Among the total cases, 26 133 (65%) were hospitalized of which 3198 (61·3%) were confirmed cases of pH1N1. From a total of 40 169 suspected cases, 450 (1·12%) were pregnant women including 169 (3·24%) confirmed cases and three (1·7%) deaths. Meanwhile, two of the 281 pregnant women with negative laboratory tests for A(H1N1) died because of pregnancy complications. Among the 40 169 suspected cases, male cases accounted for 20 282 (50·5%) and female cases for 15 646 (49·5%) with an overall male-to-female ratio of 1:1·02. The same ratio of 1:1·02 was also observed among the confirmed cases.

From the 40 169 suspected cases, 213 died, of which 156 were confirmed pH1N1 cases and 57 were negative for pandemic virus. There were no data about the causes of deaths in negative ones. The highest numbers of deaths occurred in October and November.

Of the 156 confirmed pH1N1 cases who died, the male-to-female ratio was 1·1:1, and 87 (55·7%) were aged between 20–49 years. 115 (73·7%) had at least one underlying medical condition. The most commonly reported underlying medical conditions among those who died were asthma (11, 7%), diabetes (7, 4·4%), and cardiovascular disease (7, 4·4%). Other underlying conditions such as renal disease, thalassemia, convulsion, addiction, and malignancies were present in some patients. 31 (19·8%) of deaths occurred in patients without known underlying conditions.

It is important to mention that the number of affected persons underestimates real incidence because many infected individuals do not present for testing. Meanwhile, another important underestimation is death reports. We did not have direct contact with hospitals and state health care centers, and some of them did not report death numbers every day, while the authors did not have access to patients to obtain the detailed clinical information and verify them. Finally, the data from private laboratories conducting a small number of influenza tests in Iran were not included in this study.

In conclusion, this letter was the report of epidemiological and demographic features of a large number of patients affected in the 2009 A(H1N1) pandemic in Iran. The observations were comparable to the epidemiological situation in other parts of the world.6–13 Males and females were equally affected, high rates of morbidity and mortality were observed among young adults, and pH1N1 infections were uncommon in persons older than 65 years, possibly as a result of preexisting immunity against antigenically similar influenza viruses that circulated prior to 1957. This virus continues to circulate globally and has become one of the annually circulating seasonal influenza viruses. It is important to continue to monitor it for any signs of enhanced transmissibility and pathogenesis.

Acknowledgments

We gratefully acknowledge all our colleagues in National Influenza Center, School of Public Health, Tehran University of Medical Sciences, who have worked hardly during the pandemic. We also thank the Ministry of Health & Medical Education for kind collaboration with us.

Appendix

A suspected case of pandemic A(H1N1) 2009 was defined as a patient having ILI (temperature >37·8°C, cough, sore throat, rhinorrhea, or myalgia) or at least one of the following criteria with high fever (>37·8°C):

  • 1 had close contact with a confirmed case within the past week;
  • 2 returned from a country with an epidemic of pandemic A(H1N1); and
  • 3 handled samples suspected of containing pandemic A(H1N1) virus in a laboratory within the past week.

A confirmed case was a laboratory confirmed 2009 pandemic influenza A(H1N1) infection by real-time reverse transcription–PCR performed on respiratory samples collected from suspected patients.

An imported, travel-associated case was defined as a suspected case in a person with recent travel outside the country who had arrived in Iran during the pandemic and had illness onset within 10 days of arrival.

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