Viral load at diagnosis and influenza A H1N1 (2009) disease severity in children
Article first published online: 24 MAY 2012
© 2012 Blackwell Publishing Ltd
Influenza and Other Respiratory Viruses
Volume 6, Issue 6, pages e89–e92, November 2012
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How to Cite
Launes, C., Garcia-Garcia, J. J., Jordan, I., Selva, L., Rello, J. and Muñoz-Almagro, C. (2012), Viral load at diagnosis and influenza A H1N1 (2009) disease severity in children. Influenza and Other Respiratory Viruses, 6: e89–e92. doi: 10.1111/j.1750-2659.2012.00383.x
- Issue published online: 16 OCT 2012
- Article first published online: 24 MAY 2012
- Accepted 23 April 2012. Published Online 24 May 2012.
- mechanical ventilation;
- respiratory insufficiency;
- viral load
Please cite this paper as: Launes et al. (2012) Viral load at diagnosis and influenza A H1N1 (2009) disease severity in children. Influenza and Other Respiratory Viruses 6(601), e89–e92.
To assess viral load at diagnosis (VLAD) as a biomarker of novel influenza disease severity, epidemiologic and clinical data of admitted patients <18 years old with Influenza A H1N1 (2009) infection and respiratory symptoms were prospectively collected in a single pediatric tertiary hospital, from weeks 30–51 of 2009. Seventy patients were included. VLAD in children who had symptoms for ≥5 days was an accurate parameter distinguishing the patients who required mechanical ventilation (MV) from those who did not required it (area under the ROC curve: 0·73; P = 0·03). Having <4·5 log10 copies/ml with ≥5 days of symptoms was associated with a lower risk of requiring MV.