Comparisons of oseltamivir-resistant (H275Y) and concurrent oseltamivir-susceptible seasonal influenza A(H1N1) virus infections in hospitalized adults, 2008–2009
Article first published online: 14 JUN 2012
© 2012 Blackwell Publishing Ltd
Influenza and Other Respiratory Viruses
Volume 7, Issue 3, pages 235–239, May 2013
Total views since publication: 185
How to Cite
Chan, M. C. W., Lee, N., Lui, G. C. Y., Ngai, K. K. L., Wong, R. Y. K., Choi, K.-W. and Chan, P. K. S. (2013), Comparisons of oseltamivir-resistant (H275Y) and concurrent oseltamivir-susceptible seasonal influenza A(H1N1) virus infections in hospitalized adults, 2008–2009. Influenza and Other Respiratory Viruses, 7: 235–239. doi: 10.1111/j.1750-2659.2012.00387.x
- Issue published online: 17 APR 2013
- Article first published online: 14 JUN 2012
- Accepted 30 April 2012. Published online 4 June 2012.
- seasonal influenza A(H1N1) virus
In an observational cohort study, we found that adults hospitalized for oseltamivir-resistant (H275Y) seasonal H1N1 influenza (n = 46) were older than those infected with oseltamivir-susceptible strains (n = 31) [74(IQR 59–83) versus 64(IQR 48–76) years; P = 0·045], and most had major comorbidities (78% versus 65%). Disease severity and clinical outcomes were comparable between the two groups: radiographic pneumonia 40–42%, supplemental oxygen use 47–48%, critical illness 11–13%, median duration of hospitalization 5–6 days, death rate 6–9%. Failure to receive effective antiviral therapy was associated with progression to critical illness (23% versus 0%, P = 0·016) and death (20% versus 0%, P = 0·033) in hospitalized patients with seasonal H1N1 influenza.