Tau Proteins and Neurofibrillary Degeneration
Article first published online: 28 JAN 2008
Volume 1, Issue 4, pages 279–286, July 1991
How to Cite
Goedert, M., Spillantini, M. G. and Crowther, R. A. (1991), Tau Proteins and Neurofibrillary Degeneration. Brain Pathology, 1: 279–286. doi: 10.1111/j.1750-3639.1991.tb00671.x
- Issue published online: 28 JAN 2008
- Article first published online: 28 JAN 2008
The paired helical filament is the major fibrous component of neurofibrillary pathology in Alzheimer's disease. Over the last three years evidence has accumulated that the microtubule-associated protein tau forms an important, if not the sole, constituent of the paired helical filament. Tau protein in normal brain is bound to axonal microtubules by a tandem repeat region. In Alzheimer's disease a proportion of tau protein becomes abnormally phos-phorylated and is no longer associated with axonal microtubules but instead accumulates in paired helical filaments throughout affected nerve cells. The tandem repeat region contributes substantially to the structural core of the paired helical filament, around which the amino-terminal half of the molecule forms a disordered coat.