Human Herpesvirus 6 and Multiple Sclerosis: A One-Year Follow-up Study
Article first published online: 5 APR 2006
Volume 16, Issue 1, pages 20–27, January 2006
How to Cite
Álvarez-Lafuente, R., Heras, V. D., Bartolomé, M., García-Montojo, M. and Arroyo, R. (2006), Human Herpesvirus 6 and Multiple Sclerosis: A One-Year Follow-up Study. Brain Pathology, 16: 20–27. doi: 10.1111/j.1750-3639.2006.tb00558.x
- Issue published online: 5 APR 2006
- Article first published online: 5 APR 2006
Background. This study was undertaken in order to investigate the possible relation of HHV-6 and EBV in relapsing-remitting MS (RRMS).
Materials and methods. A one-year follow up study was performed analysing peripheral blood mononuclear cells and serum samples of 57 patients with RRMS and 57 healthy blood donors (HBD) by a quantitative real time PCR, to detect HHV-6 and EBV. Clinical data (starting age and EDSS increase) were collected.
Results. We did not find any statistically significant difference for EBV between RRMS patients and HBD. Regarding HHV-6: i) There was a higher prevalence of HHV-6 in RRMS patients than in controls: 80.7% versus 29.8% respectively. ii) HHV-6 active replication seems to be related to exacerbations. iii) Only variant A was detected among RRMS patients with HHV-6 active replication. iv) Although some difference was found when we compared clinical data in RRMS patients with and without HHV-6 active replication, the results did not reach statistical significance.
Conclusions. A higher HHV-6A frequency of active infection (reactivation or new infection) would lead to a more frequent exposure of HHV-6A antigens to the immune system of RRMS patients; this active replication of HHV-6A seems to be specifically related with the exacerbations in a subset of RRMS patients.