These authors contributed equally to this work.
MiR-92b and miR-9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors
Article first published online: 8 JUL 2008
© 2008 Rosetta Genomics Ltd; © 2008 International Society of Neuropathology
Volume 19, Issue 3, pages 375–383, July 2009
How to Cite
Nass, D., Rosenwald, S., Meiri, E., Gilad, S., Tabibian-Keissar, H., Schlosberg, A., Kuker, H., Sion-Vardy, N., Tobar, A., Kharenko, O., Sitbon, E., Lithwick Yanai, G., Elyakim, E., Cholakh, H., Gibori, H., Spector, Y., Bentwich, Z., Barshack, I. and Rosenfeld, N. (2009), MiR-92b and miR-9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors. Brain Pathology, 19: 375–383. doi: 10.1111/j.1750-3639.2008.00184.x
- Issue published online: 10 JUN 2009
- Article first published online: 8 JUL 2008
- Received 11 December 2007; revised 29 April 2008; accepted 30 April 2008.
- MicroRNA expression;
- Molecular diagnostics;
- Tumor classification
A recurring challenge for brain pathologists is to diagnose whether a brain malignancy is a primary tumor or a metastasis from some other tissue. The accurate diagnosis of brain malignancies is essential for selection of proper treatment. MicroRNAs are a class of small non-coding RNA species that regulate gene expression; many exhibit tissue-specific expression and are misregulated in cancer. Using microRNA expression profiling, we found that hsa-miR-92b and hsa-miR-9/hsa-miR-9* are over-expressed, specifically in brain primary tumors, as compared to primary tumors from other tissues and their metastases to the brain. By considering the expression of only these two microRNAs, it is possible to distinguish between primary and metastatic brain tumors with very high accuracy. These microRNAs thus represent excellent biomarkers for brain primary tumors. Previous reports have found that hsa-miR-92b and hsa-miR-9/hsa-miR-9* are expressed more strongly in developing neurons and brain than in adult brain. Thus, their specific over-expression in brain primary tumors supports a functional role for these microRNAs or a link between neuronal stem cells and brain tumorigenesis.