Brain Extracellular Matrix in Neurodegeneration
Article first published online: 25 JUL 2008
© 2008 The Authors. Journal Compilation © 2008 International Society of Neuropathology
Volume 19, Issue 4, pages 573–585, October 2009
How to Cite
Bonneh-Barkay, D. and Wiley, C. A. (2009), Brain Extracellular Matrix in Neurodegeneration. Brain Pathology, 19: 573–585. doi: 10.1111/j.1750-3639.2008.00195.x
- Issue published online: 4 SEP 2009
- Article first published online: 25 JUL 2008
- Received 18 February 2008; accepted 27 May 2008.
The role of extracellular matrix (ECM) in neurological development, function and degeneration has evolved from a simplistic physical adhesion to a system of intricate cellular signaling. While most cells require ECM adhesion to survive, it is now clear that differentiated function is intimately dependent upon cellular interaction with the ECM. Therefore, it is not surprising that the ECM is increasingly found to be involved in the enigmatic process of neurodegeneration. Descriptive studies of human neurodegenerative disorders and experimental studies of animal models of neurodegeneration have begun to define potential mechanisms of ECM disruption that can lead to synaptic and neuronal loss.