Neuropathogenesis of Naturally Occurring Encephalitis Caused by Listeria monocytogenes in Ruminants
Version of Record online: 20 MAY 2009
© 2009 The Authors; Journal Compilation © 2009 International Society of Neuropathology
Volume 20, Issue 2, pages 378–390, March 2010
How to Cite
Oevermann, A., Di Palma, S., Doherr, M. G., Abril, C., Zurbriggen, A. and Vandevelde, M. (2010), Neuropathogenesis of Naturally Occurring Encephalitis Caused by Listeria monocytogenes in Ruminants. Brain Pathology, 20: 378–390. doi: 10.1111/j.1750-3639.2009.00292.x
- Issue online: 2 FEB 2010
- Version of Record online: 20 MAY 2009
- Received 12 February 2009; revised 3 March 2009; accepted 10 March 2009.
- Listeria monocytogenes;
- Axonal spread;
- Intracerebral spread
Listeriosis is a serious food-borne disease with increasing frequency in humans and ruminants. Despite the facts that in both hosts, listeriosis can occur as rhombencephalitis and ruminants are a reservoir of Listeria monocytogenes (LM) strains pathogenic for humans, little work has been done on the pathogenesis in ruminants. This study investigates the neuropathogenesis of listeric encephalitis in over 200 natural cases in cattle, sheep and goats by analyzing anatomical distribution, severity, bacterial load and temporal evolution of the lesions. Our results suggest that LM gains access to the brainstem of all three species via axonal migration not only along the trigeminal nerve, but also along other nerves. The ensuing encephalitis does not remain restricted to the brainstem. Rather, LM spreads further from the brainstem into rostral brain regions likely by intracerebral axonal migration. Significant differences in severity of the lesions and bacterial load were found between cattle and small ruminants, which may be caused by species-specific properties of antibacterial immune responses. As histopathological lesions of human rhombencephalitis caused by LM strongly resemble those of ruminants, the disease likely has a similar pathogenesis in both hosts.