Association Between Lifetime Cigarette Smoking and Lewy Body Accumulation
Article first published online: 15 JUN 2009
© 2009 The Authors; Journal Compilation © 2009 International Society of Neuropathology
Volume 20, Issue 2, pages 412–418, March 2010
How to Cite
Tsuang, D., Larson, E. B., Li, G., Shofer, J. B., Montine, K. S., Thompson, M. L., Sonnen, J. A., Crane, P. K., Leverenz, J. B. and Montine, T. J. (2010), Association Between Lifetime Cigarette Smoking and Lewy Body Accumulation. Brain Pathology, 20: 412–418. doi: 10.1111/j.1750-3639.2009.00296.x
- Issue published online: 2 FEB 2010
- Article first published online: 15 JUN 2009
- Received 27 February 2009; accepted 4 April 2009.
- Alzheimer's disease;
- Lewy body;
Cigarette smoking has been associated repeatedly in observational studies with decreased risk of Parkinson's disease (PD), but its relationship to the risk of dementia or Alzheimer's disease (AD) is inconsistent. All of these studies have used clinical diagnoses of disease. We tested the hypothesis that lifetime cigarette use might be associated with reduced risk of neuropathologic changes of Lewy-related pathology (LRP) in multiple brain regions or with reduced risk of consensus neuropathologic changes of AD in a prospective community-based study of brain aging and dementia, the Adult Changes in Thought (ACT) study. We observed that heavy lifetime cigarette smoking (>50 pack years) was associated with significantly reduced relative risk (RR) for LRP, but not AD-type pathologic changes, after correcting for selection bias, and with significantly reduced frequency of LRP in the substantia nigra. These findings are the first of which we are aware to associate reduced LRP in human brain with any exposure, and substantiate observational studies that have associated cigarette smoking with reduced risk of PD. Although cigarette smoking is too toxic to suggest as a treatment, if confirmed, these findings may guide future therapeutic strategies that attempt to suppress LRP in human brain by other means.