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Figure S1. Correlation of [F-18]FDDNP Logan analysis approaches: white matter vs. cerebellum as reference region.

Figure S2. Coronal T1 magnetic resonance images. Evidence of ventricular dilation and atrophy.

Figure S3. [F-18]FDDNP DVR scatter plots for several cortical regions (A–E) and cerebellum (F).

Figure S4. Scatter plots for global (I) and regional cortical (A–E), striatal (G), thalamic (H) and cerebellar (F) [F-18]FDG SUVR values.

Figure S5. Scatter plots of [F-18]FDDNP R1 values in striatum (left) and thalamus (right).

Table S1. [F-18]FDDNP DVR Z scores in reference to the control group.

Table S2. [F-18]FDG SUVR Z scores in reference to the control group.

Table S3. Grading of clinical symptoms.

Table S4. Results of neuropsychological testing of Gerstmann–Sträussler–Scheinker subjects at the time of PET/MRI scans.

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