Contributors: VK, BG, MRF, MB, S-CH, GWS and JRB participated in the design of the study. VK, BG, MRF, KM, FE, JL, NS, GWS and JRB were instrumental in performing the imaging study. VK, S-CH, KPW and JRB developed image analysis methodology and analyzed the imaging data. MB, GR, LMS and AP performed in vitro tissue labeling experiments and analysis. VK, BG, MRF, MG, KM, S-CH, JRM, PP, LMS, PS, GWS and JRB evaluated the data. VK, BG, MB and JRB contributed to the development of the first draft. VK and JRB developed the final draft. All authors contributed to the writing and the revision of this paper, and approved the final version.
PET of Brain Prion Protein Amyloid in Gerstmann–Sträussler–Scheinker Disease
Article first published online: 9 JUN 2009
© 2009 The Authors. Journal Compilation © 2009 International Society of Neuropathology
Volume 20, Issue 2, pages 419–430, March 2010
How to Cite
Kepe, V., Ghetti, B., Farlow, M. R., Bresjanac, M., Miller, K., Huang, S.-C., Wong, K.-P., Murrell, J. R., Piccardo, P., Epperson, F., Repovš, G., Smid, L. M., Petrič, A., Siddarth, P., Liu, J., Satyamurthy, N., Small, G. W. and Barrio, J. R. (2010), PET of Brain Prion Protein Amyloid in Gerstmann–Sträussler–Scheinker Disease. Brain Pathology, 20: 419–430. doi: 10.1111/j.1750-3639.2009.00306.x
- Issue published online: 2 FEB 2010
- Article first published online: 9 JUN 2009
- Received 17 February 2009; accepted 27 April 2009.
Figure S1. Correlation of [F-18]FDDNP Logan analysis approaches: white matter vs. cerebellum as reference region.
Figure S2. Coronal T1 magnetic resonance images. Evidence of ventricular dilation and atrophy.
Figure S3. [F-18]FDDNP DVR scatter plots for several cortical regions (A–E) and cerebellum (F).
Figure S4. Scatter plots for global (I) and regional cortical (A–E), striatal (G), thalamic (H) and cerebellar (F) [F-18]FDG SUVR values.
Figure S5. Scatter plots of [F-18]FDDNP R1 values in striatum (left) and thalamus (right).
Table S1. [F-18]FDDNP DVR Z scores in reference to the control group.
Table S2. [F-18]FDG SUVR Z scores in reference to the control group.
Table S3. Grading of clinical symptoms.
Table S4. Results of neuropsychological testing of Gerstmann–Sträussler–Scheinker subjects at the time of PET/MRI scans.
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