Present address: Department of Psychiatry, University of California, San Diego, La Jolla, Ca.
Cerebral Microinfarcts Associated with Severe Cerebral β-Amyloid Angiopathy
Article first published online: 16 JUL 2009
© 2009 The Authors. Journal Compilation © 2009 International Society of Neuropathology
Volume 20, Issue 2, pages 459–467, March 2010
How to Cite
Soontornniyomkij, V., Lynch, M. D., Mermash, S., Pomakian, J., Badkoobehi, H., Clare, R. and Vinters, H. V. (2010), Cerebral Microinfarcts Associated with Severe Cerebral β-Amyloid Angiopathy. Brain Pathology, 20: 459–467. doi: 10.1111/j.1750-3639.2009.00322.x
- Issue published online: 2 FEB 2010
- Article first published online: 16 JUL 2009
- Received 15 April 2009; accepted 17 June 2009.
- cerebrovascular disease;
- multi-infarct dementia;
- vascular dementia
Cerebral amyloid angiopathy (CAA) is common in elderly individuals, especially those affected with Alzheimer's disease. Eighteen brains with severe SCAA (SCAA) were compared with 21 brains with mild CAA (MCAA) to investigate whether the presence of SCAA in the brains of demented patients was associated with a higher burden of old microinfarcts than those with MCAA. Immunohistochemistry for CD68 was employed to highlight old microinfarcts in tissue blocks from various brain regions. Old microinfarcts, manually counted by light microscopy, were present in 14 of 18 SCAA brains and in 7 of 21 MCAA brains (P = 0.01, two-tailed Fisher's exact test). The average number of old microinfarcts across geographic regions in each brain ranged from 0 to 1.95 (mean rank 24.94, sum of ranks 449) in the SCAA group, and from 0 to 0.35 (mean rank 15.76, sum of ranks 331) in the MCAA group (P = 0.008, two-tailed Mann–Whitney U-test). Frequent old microinfarcts in demented individuals with severe CAA may contribute a vascular component to the cognitive impairment in these patients.