Authors contributed equally to this work.
Upregulation of Immunoglobulin-related Genes in Cortical Sections from Multiple Sclerosis Patients
Version of Record online: 16 OCT 2009
© 2009 The Authors; Journal Compilation © 2009 International Society of Neuropathology
Volume 20, Issue 4, pages 720–729, July 2010
How to Cite
Torkildsen, Ø., Stansberg, C., Angelskår, S. M., Kooi, E.-J., Geurts, J. J.G., Van Der Valk, P., Myhr, K.-M., Steen, V. M. and Bø, L. (2010), Upregulation of Immunoglobulin-related Genes in Cortical Sections from Multiple Sclerosis Patients. Brain Pathology, 20: 720–729. doi: 10.1111/j.1750-3639.2009.00343.x
- Issue online: 7 JUN 2010
- Version of Record online: 16 OCT 2009
- Received 5 August 2009; accepted 6 October 2009.
Figure S1. Immunohistochemical staining of the EBV-positive cell line B95.8. The figure shows LMP1 positive cells (arrow) (A) and nuclear localisation of the EBNA2 antigen (arrow) (B) in the B95.8 transformed cell line. There were no LMP1 or EBNA2 positive cells in the brains or meninges of the MS patients (stainings not shown). All pictures have an original magnification of × 40.
Table S1. Genes differentially expressed (q = 5) between cortical samples from MS patients and controls. Up- and down-regulated genes are presented as separate worksheets in the excel-file.
Table S2. Prominent Panther functional categories over-represented among genes up- and down-regulated in MS brains. The lists of up- and down-regulated genes were compared to the entire list of genes that showed detectable expression in at least one of the samples included in the study (24 426 genes, S/N ≥ 3) on the Applied Biosystems Human Genome Survey Array. Statistically significant over- and under-represented annotation categories were determined by binomial statistics, using the observed number of genes versus the numbers expected by chance within a certain annotation group.
Please note: Wiley-Blackwell are not responsible for the content or functionality of any supporting materials supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the article.
|BPA_343_sm_Figure_1.jpg||143K||Supporting info item|
|BPA_343_sm_Table_1.xls||3057K||Supporting info item|
|BPA_343_sm_Table_2.xls||24K||Supporting info item|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.