Glioblastoma, Cancer Stem Cells and Hypoxia
Article first published online: 30 NOV 2010
© 2010 The Author. Brain Pathology © 2010 International Society of Neuropathology
Volume 21, Issue 2, pages 119–129, March 2011
How to Cite
Bar, E. E. (2011), Glioblastoma, Cancer Stem Cells and Hypoxia. Brain Pathology, 21: 119–129. doi: 10.1111/j.1750-3639.2010.00460.x
- Issue published online: 27 JAN 2011
- Article first published online: 30 NOV 2010
- Accepted manuscript online: 5 NOV 2010 04:59AM EST
- Received 9 August 2010; accepted 26 October 2010.
- cancer stem cells;
- side population
Glioblastoma (GBM) prognosis remains dismal, with most patients succumbing to disease within 1 or 2 years of diagnosis. Recent studies have suggested that many solid tumors, including GBM, are maintained by a subset of cells termed cancer stem cells (CSCs). It has been shown that these cells are inherently radio- and chemotherapy resistant, and may be maintained in vivo in a niche characterized by reduced oxygen tension (hypoxia). This review examines the recently described effects of hypoxia on CSC in GBM, and the potential promise in targeting the hypoxic pathway therapeutically.