These authors contributed equally to this work.
ALDH1A1 is a Marker of Astrocytic Differentiation during Brain Development and Correlates with Better Survival in Glioblastoma Patients
Article first published online: 19 APR 2012
© 2012 The Authors; Brain Pathology © 2012 International Society of Neuropathology
Volume 22, Issue 6, pages 788–797, November 2012
How to Cite
Adam, S. A., Schnell, O., Pöschl, J., Eigenbrod, S., Kretzschmar, H. A., Tonn, J.-C. and Schüller, U. (2012), ALDH1A1 is a Marker of Astrocytic Differentiation during Brain Development and Correlates with Better Survival in Glioblastoma Patients. Brain Pathology, 22: 788–797. doi: 10.1111/j.1750-3639.2012.00592.x
- Issue published online: 11 OCT 2012
- Article first published online: 19 APR 2012
- Accepted manuscript online: 14 MAR 2012 06:43AM EST
- Received 28 November 2011; Accepted 1 March 2012; Published Online Article Accepted 14 March 2012
Glioblastoma is the most common malignant brain tumor and patients usually succumb to their disease within 2 years. Aldehyde dehydrogenase 1A1 (ALDH1A1) has been suggested as a marker for cancer stem cells that is associated with poor prognosis in human gliomas. However, little is known about the expression and the function of ALDH1A1 in early stages of brain development. We analyzed ALDH1A1 expression in developing and mature central nervous system (CNS) as well as in 93 cases of primary glioblastomas. Surprisingly, ALDH1A1 was absent in the stem cell niches at varying stages of CNS development, but strong ALDH1A1 expression was observed in mature astrocytes coexpressing GFAP and S100. There were 92 out of 93 glioblastomas (99%) that showed ALDH1A1 protein expression in up to 49% of tumor cells. The majority of these cells co-expressed GFAP, but not established stem cell markers such as Nestin, OLIG2 or SOX2. Finally, strong expression of ALDH1A1 correlated with a significantly better survival of the patients and proved to be an independent prognostic marker in our series (P < 0.01). In contrast to other published data, we therefore provide evidence for ALDH1A1 as a marker of astrocytic differentiation during brain development and of better prognosis in patients suffering from primary glioblastoma.