These authors contributed equally.
Postischemic Brain Infiltration of Leukocyte Subpopulations Differs among Murine Permanent and Transient Focal Cerebral Ischemia Models
Version of Record online: 6 AUG 2012
© 2012 The Authors; Brain Pathology © 2012 International Society of Neuropathology
Volume 23, Issue 1, pages 34–44, January 2013
How to Cite
Zhou, W., Liesz, A., Bauer, H., Sommer, C., Lahrmann, B., Valous, N., Grabe, N. and Veltkamp, R. (2013), Postischemic Brain Infiltration of Leukocyte Subpopulations Differs among Murine Permanent and Transient Focal Cerebral Ischemia Models. Brain Pathology, 23: 34–44. doi: 10.1111/j.1750-3639.2012.00614.x
- Issue online: 7 DEC 2012
- Version of Record online: 6 AUG 2012
- Accepted manuscript online: 9 JUL 2012 06:10AM EST
- Manuscript Accepted: 24 JUN 2012
- Manuscript Received: 30 JAN 2012
- German Excellence program “FRONTIER”
- Deutsche Forschungsgemeinschaft. Grant Number: VE.196/3-1
Figure S1. Schematic overview of different MCAO models and resulting infarct demarcation on histological sections. (A) Left: in transient MCAO caused by the intraluminal filament, the origin of the MCAO is occluded. Right: transtemporal electrocoagulation of the MCAO is performed beyond the branching of the lenticulostriate arteries. Site of occlusion is marked in red. ACA = anterior cerebral artery; MCA = middle cerebral artery; PCA = posterior cerebral artery; BA = basilar artery; ICA = internal carotid artery. (B) Resulting infarcts depend on the site of occlusion and the duration of ischemia. Representative cresyl-violett stained cryosection of the analyzed stroke models, infarct areas are encircled. Comparison of infarct volume (C) and mortality (D) at 24 h and 5 days among the MCAO models.
Figure S2. Schematic overview of the fields of interest (FOIs) for comparison of activated microglia; 6x FOIs (each 0.16 mm2) surrounding the infarct area in the ischemic hemisphere and corresponding areas in the nonischemic hemisphere were defined on the immunohistochemistry sections for Iba1 of the analyzed stroke models to evaluate the activated microglia.
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.