American Ginseng Berry Juice Intake Reduces Blood Glucose and Body Weight in ob/ob Mice

Authors

  • J.T. Xie,

    1. The authors are with Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology and Pharmacogenomics, and Dept. of Anesthesia & Critical Care, The Pritzker School of Medicine, Univ. of Chicago, Chicago, IL 60637, U.S.A. Direct inquiries to author Yuan (E-mail: cyuan@airway.uchicago.edu).
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  • C.Z. Wang,

    1. The authors are with Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology and Pharmacogenomics, and Dept. of Anesthesia & Critical Care, The Pritzker School of Medicine, Univ. of Chicago, Chicago, IL 60637, U.S.A. Direct inquiries to author Yuan (E-mail: cyuan@airway.uchicago.edu).
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  • M. Ni,

    1. The authors are with Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology and Pharmacogenomics, and Dept. of Anesthesia & Critical Care, The Pritzker School of Medicine, Univ. of Chicago, Chicago, IL 60637, U.S.A. Direct inquiries to author Yuan (E-mail: cyuan@airway.uchicago.edu).
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  • J.A. Wu,

    1. The authors are with Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology and Pharmacogenomics, and Dept. of Anesthesia & Critical Care, The Pritzker School of Medicine, Univ. of Chicago, Chicago, IL 60637, U.S.A. Direct inquiries to author Yuan (E-mail: cyuan@airway.uchicago.edu).
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  • S.R. Mehendale,

    1. The authors are with Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology and Pharmacogenomics, and Dept. of Anesthesia & Critical Care, The Pritzker School of Medicine, Univ. of Chicago, Chicago, IL 60637, U.S.A. Direct inquiries to author Yuan (E-mail: cyuan@airway.uchicago.edu).
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  • H.H. Aung,

    1. The authors are with Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology and Pharmacogenomics, and Dept. of Anesthesia & Critical Care, The Pritzker School of Medicine, Univ. of Chicago, Chicago, IL 60637, U.S.A. Direct inquiries to author Yuan (E-mail: cyuan@airway.uchicago.edu).
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  • A. Foo,

    1. The authors are with Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology and Pharmacogenomics, and Dept. of Anesthesia & Critical Care, The Pritzker School of Medicine, Univ. of Chicago, Chicago, IL 60637, U.S.A. Direct inquiries to author Yuan (E-mail: cyuan@airway.uchicago.edu).
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  • C.S. Yuan

    1. The authors are with Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology and Pharmacogenomics, and Dept. of Anesthesia & Critical Care, The Pritzker School of Medicine, Univ. of Chicago, Chicago, IL 60637, U.S.A. Direct inquiries to author Yuan (E-mail: cyuan@airway.uchicago.edu).
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Abstract

ABSTRACT:  Diabetes is a serious chronic metabolic disease and has a significant impact on patients' lives and the health care system. We previously observed that the organic solvent extract of American ginseng berry possessed significant antidiabetic effects in obese diabetic ob/ob mice after intraperitoneal injection. If American ginseng berry is useful as a dietary supplement, simple preparation and oral intake would be a convenient, safe, and practical means for consumers. In this study, the simply prepared berry juice was first analyzed using high-performance liquid chromatography, and then administered orally in the ob/ob mice. The animals received daily berry juice 0.6 mL/kg or vehicle for 10 consecutive days. The results indicated that oral juice administration significantly lowered fasting blood glucose levels, and this effect continued for at least 10 d after cessation of the treatment. Data from intraperitoneal glucose tolerance test demonstrated that there was a notable improvement in glucose tolerance in the juice treated group. In addition, the berry juice significantly reduced body weight. Our data suggest that ginseng berry juice, as a dietary supplement, may have functional efficacy in consumers with diabetes.

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