Antiobesity Effects of Undaria Lipid Capsules Prepared with Scallop Phospholipids

Authors

  • Tomoko Okada,

    1. Author Okada is with Dept. of Food Science, Obihiro Univ. of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Authors Mizuno, Hosokawa, and Miyashita are with Graduate School of Fisheries Sciences, Faculty of Fisheries, Hokkaido Univ. 3-1, Minatocho, Hakodateshi, Hokkaido 041-0821, Japan. Author Shibayama is with Cosmo Foods Co., Ltd., The Azumaya building 7th floor, 12-2 Kodenmacho, Nihonbashi, Chuoku, Tokyo 103-0001, Japan. Direct inquiries to author Okada (E-mail: okadat@obihiro.ac.jp).
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  • Yasuyuki Mizuno,

    1. Author Okada is with Dept. of Food Science, Obihiro Univ. of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Authors Mizuno, Hosokawa, and Miyashita are with Graduate School of Fisheries Sciences, Faculty of Fisheries, Hokkaido Univ. 3-1, Minatocho, Hakodateshi, Hokkaido 041-0821, Japan. Author Shibayama is with Cosmo Foods Co., Ltd., The Azumaya building 7th floor, 12-2 Kodenmacho, Nihonbashi, Chuoku, Tokyo 103-0001, Japan. Direct inquiries to author Okada (E-mail: okadat@obihiro.ac.jp).
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  • Shinichi Sibayama,

    1. Author Okada is with Dept. of Food Science, Obihiro Univ. of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Authors Mizuno, Hosokawa, and Miyashita are with Graduate School of Fisheries Sciences, Faculty of Fisheries, Hokkaido Univ. 3-1, Minatocho, Hakodateshi, Hokkaido 041-0821, Japan. Author Shibayama is with Cosmo Foods Co., Ltd., The Azumaya building 7th floor, 12-2 Kodenmacho, Nihonbashi, Chuoku, Tokyo 103-0001, Japan. Direct inquiries to author Okada (E-mail: okadat@obihiro.ac.jp).
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  • Masashi Hosokawa,

    1. Author Okada is with Dept. of Food Science, Obihiro Univ. of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Authors Mizuno, Hosokawa, and Miyashita are with Graduate School of Fisheries Sciences, Faculty of Fisheries, Hokkaido Univ. 3-1, Minatocho, Hakodateshi, Hokkaido 041-0821, Japan. Author Shibayama is with Cosmo Foods Co., Ltd., The Azumaya building 7th floor, 12-2 Kodenmacho, Nihonbashi, Chuoku, Tokyo 103-0001, Japan. Direct inquiries to author Okada (E-mail: okadat@obihiro.ac.jp).
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  • Kazuo Miyashita

    1. Author Okada is with Dept. of Food Science, Obihiro Univ. of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Authors Mizuno, Hosokawa, and Miyashita are with Graduate School of Fisheries Sciences, Faculty of Fisheries, Hokkaido Univ. 3-1, Minatocho, Hakodateshi, Hokkaido 041-0821, Japan. Author Shibayama is with Cosmo Foods Co., Ltd., The Azumaya building 7th floor, 12-2 Kodenmacho, Nihonbashi, Chuoku, Tokyo 103-0001, Japan. Direct inquiries to author Okada (E-mail: okadat@obihiro.ac.jp).
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Abstract

Abstract:  Based on previous research findings, a capsule was developed containing n-3 polyunsaturated fatty acid rich scallop phospholipids (PLs) with an incorporation of brown seaweed (Undaria pinnatifida) lipids (ULs) containing fucoxanthin. The antiobesity effects of the capsules were evaluated with an animal model using 3-wk-old male KK-Ay mice. Each group received different combinations of lipid (UL, PL, UL + PL, or UL + PL capsule) either incorporated into the diet or into drinking water. Animals were sacrificed after a 4-wk experimental feeding period, and adipose tissues and organs were dissected and weighed. Blood samples were obtained to determine plasma lipid profiles. Uncoupling protein 1 (UCP1) mRNA expression levels were determined by real-time polymerase chain reaction analysis, and UCP1 expression was determined by western blotting analysis. Treatment with either UL alone or UL + PL (capsule) through drinking water resulted in a significant reduction in body weight, compared to the control group. The total white adipose tissue weight of mice fed the UL + PL capsule in drinking water was significantly reduced. Both UCP1 and UCP1 mRNA expression in epididymal fat from mice fed the capsule were significantly higher than in the control group. These results suggest that incorporation of UL into scallop-derived PL by means of capsulation may lead to an additive increase in the antiobesity properties of these bioactive lipids.

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