Effect of Diallyl Trisulfide on the Pharmacokinetics of Nifedipine in Rats
Article first published online: 6 JAN 2011
© 2010 Institute of Food Technologists®
Journal of Food Science
Volume 76, Issue 1, pages T30–T34, January/February 2011
How to Cite
Wang, Y., Zou, M.-J., Zhao, N., Ren, J.-G., Zhou, H. and Cheng, G. (2011), Effect of Diallyl Trisulfide on the Pharmacokinetics of Nifedipine in Rats. Journal of Food Science, 76: T30–T34. doi: 10.1111/j.1750-3841.2010.01960.x
- Issue published online: 13 JAN 2011
- Article first published online: 6 JAN 2011
- MS 20100902 Submitted 8/9/2010, Accepted 10/18/2010.
- diallyl trisulfide;
- food–drug interaction;
Abstract: This study aimed to evaluate the effect of diallyl trisulfide (DATS), a major component derived from garlic, on the pharmacokinetics of nifedipine. Pharmacokinetic parameters of nifedipine were determined in rats following an oral gavage (3 mg/kg) or intravenous administration (0.75 mg/kg) of nifedipine with co-administration of DATS (20 mg/kg) and long-term pretreatment of DATS (20 mg/kg/d for 15 consecutive days). Compared to the control groups, higher Cmax and AUC0–24 h were observed for oral gavage of nifedipine after short-term and long-term pretreatment of DATS, whereas those for intravenous nifedipine were little changed. The oral bioavailabilities of nifedipine were remarkably enhanced via the concomitant use of DATS. In conclusion, DATS increased the oral exposure of nifedipine in rats likely by the modification of intestinal metabolism of nifedipine, indicating that combined use of DATS or DATS-containing supplement with nifedipine may require caution because high plasma concentrations may lead to an undesired toxicity of this agent.
Practical Application: Patients suffering from cardiovascular disease should take caution in combined use of DATS or DATS-rich garlic supplement with nifedipine because long-term treatment of DATS could lead high plasma concentrations of nifedipine.