Effect of Amino Acids on Red Pigments and Citrinin Production in Monascus ruber

Authors

  • Hassan Hajjaj,

    1. Author Hajjaj is with Laboratoire de Biotechnologie Végétale et Biologie Moléculaire, Dépt. de Biologie, Faculté des Sciences, Univ. Moulay Ismail, B.P. 11201 Zitoune, Meknès, Morocco. Authors François, Goma, and Blanc are with Université de Toulouse, INSA, LISBP, CNRS, UMR5504, INRA, UMR792, Ingénierie des Systèmes Biologiques et des Procédés, 135 Avenue de Rangueil, F-31077 Toulouse, France (E-mail: h_hajjaj@yahoo.com)
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  • Jean-Marie François,

    1. Author Hajjaj is with Laboratoire de Biotechnologie Végétale et Biologie Moléculaire, Dépt. de Biologie, Faculté des Sciences, Univ. Moulay Ismail, B.P. 11201 Zitoune, Meknès, Morocco. Authors François, Goma, and Blanc are with Université de Toulouse, INSA, LISBP, CNRS, UMR5504, INRA, UMR792, Ingénierie des Systèmes Biologiques et des Procédés, 135 Avenue de Rangueil, F-31077 Toulouse, France (E-mail: h_hajjaj@yahoo.com)
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  • Gérard Goma,

    1. Author Hajjaj is with Laboratoire de Biotechnologie Végétale et Biologie Moléculaire, Dépt. de Biologie, Faculté des Sciences, Univ. Moulay Ismail, B.P. 11201 Zitoune, Meknès, Morocco. Authors François, Goma, and Blanc are with Université de Toulouse, INSA, LISBP, CNRS, UMR5504, INRA, UMR792, Ingénierie des Systèmes Biologiques et des Procédés, 135 Avenue de Rangueil, F-31077 Toulouse, France (E-mail: h_hajjaj@yahoo.com)
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  • Philippe J. Blanc

    1. Author Hajjaj is with Laboratoire de Biotechnologie Végétale et Biologie Moléculaire, Dépt. de Biologie, Faculté des Sciences, Univ. Moulay Ismail, B.P. 11201 Zitoune, Meknès, Morocco. Authors François, Goma, and Blanc are with Université de Toulouse, INSA, LISBP, CNRS, UMR5504, INRA, UMR792, Ingénierie des Systèmes Biologiques et des Procédés, 135 Avenue de Rangueil, F-31077 Toulouse, France (E-mail: h_hajjaj@yahoo.com)
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Abstract

ABSTRACT:  Amino acids were used as sole nitrogen sources to examine their effects on the production of water-soluble red pigments and citrinin by Monascus ruber ATCC 96218 cultivated on chemically defined media. In general, when glycine, tyrosine, arginine, serine, or histidine were used as sole nitrogen sources, they favored the production of red pigments, and restricted the synthesis of the mycotoxin. In contrast, the production of citrinin was enhanced in media supplemented with either glutamate, alanine, or proline. Histidine was found to be the most valuable amino acid as it resulted in the highest production of red pigments and almost completely eliminated the formation of mycotoxin.

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