Antagonistic Effect of the Ainu-Selected Traditional Beneficial Plants on the Transformation of an Aryl Hydrocarbon Receptor
Article first published online: 6 MAR 2012
© 2012 Institute of Food Technologists®
Journal of Food Science
Volume 77, Issue 4, pages C420–C429, April 2012
How to Cite
Nishiumi, S., Hosokawa, K., Anetai, M., Shibata, T., Mukai, R., Yoshida, K.-i. and Ashida, H. (2012), Antagonistic Effect of the Ainu-Selected Traditional Beneficial Plants on the Transformation of an Aryl Hydrocarbon Receptor. Journal of Food Science, 77: C420–C429. doi: 10.1111/j.1750-3841.2011.02611.x
- Issue published online: 19 APR 2012
- Article first published online: 6 MAR 2012
- MS 20111085 Submitted 9/10/2011, Accepted 12/13/2011.
- antioxidative activity;
- the Ainu
Abstract: Transformation of an aryl hydrocarbon receptor (AhR) is the initial step to express the multiple toxicity of halogenated and polycyclic aromatic hydrocarbons (HAHs and PAHs) including dioxins. Therefore, it has been suggested that suppression of the transformation induced by HAHs and PAHs leads to reduce their toxicological effects. In this study, the antagonistic effect of 110 indigenous plants (192 plant parts) used as medicine and/or food by the Ainu on the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced AhR transformation was investigated. Of these, a stalk of Aralia elata (Miq.) Seemann and a bark of Fraxinus mandshurica Rupr. var. japonica Maxim. exhibited the strong antagonistic effect in a dose-dependent manner. An antioxidative activity and polyphenol content were also measured, and the strong correlation (r= 0.96) between these two parameters could be confirmed. However, correlation coefficients of the antagonistic effect of 192 extracts compared to their antioxidative activity and polyphenol content were 0.17 and 0.20, respectively. These results suggest that the Ainu-selected traditional beneficial plants are useful source for findings of novel AhR antagonists, and the antagonistic activity of these plants may be independent on their antioxidative activity and polyphenol content.
Practical Application: Our findings lead to discovery of the valuable plants used by the Ainu and the novel active compounds useful for human's life, and furthermore, may contribute to the development of new medicines and functional foods.