Abstract: The volatile compounds of Panax ginseng C.A. Meyer analyzed to interpret whether cultivation methods affect volatile compounds. The volatile compounds in Panax ginseng C.A. Meyer cultured with 3 different cultivation methods such as good agricultural practice, organic cultivation method, and general cultivation method were isolated by solid-phase microextraction fiber (polydimethylsiloxane 65 μm) and identified by gas chromatography mass spectrometry. Then, the scattering patterns of volatile compounds compared by principal component analysis. As the results, the 14 volatile compounds were identified from 30 ginseng samples and consisted mainly of sesquiterpene hydrocarbons. The differences among the different cultivation methods of the samples were obvious from the PC1 and PC2 scatter point plot. As the conclusion, the cultivation methods can affect to produce the volatile component of ginseng root. The organic and good agriculture practice cultivation can increase the ginseng characteristic volatile compounds.