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Hypolipidemic Activity in Sprague–Dawley Rats and Constituents of a Novel Natural Vegetable Oil from Cornus Wilsoniana Fruits

Authors

  • Jie Fu,

    1. Authors Fu, X-W Zhang, Liu, Q-S Li, L-R Zhang, Yang, Z-M Zhang, Luo, He, Zhu are with State Key Lab. of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univ., Nanjing 210093, China. Author C-Z Li is with Hu’nan Academy of Forestry, Changsha 410004, China. Direct inquiries to author Zhu (E-mail address: zhuhl@nju.edu.cn).
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  • Xue-Wei Zhang,

    1. Authors Fu, X-W Zhang, Liu, Q-S Li, L-R Zhang, Yang, Z-M Zhang, Luo, He, Zhu are with State Key Lab. of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univ., Nanjing 210093, China. Author C-Z Li is with Hu’nan Academy of Forestry, Changsha 410004, China. Direct inquiries to author Zhu (E-mail address: zhuhl@nju.edu.cn).
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  • Kai Liu,

    1. Authors Fu, X-W Zhang, Liu, Q-S Li, L-R Zhang, Yang, Z-M Zhang, Luo, He, Zhu are with State Key Lab. of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univ., Nanjing 210093, China. Author C-Z Li is with Hu’nan Academy of Forestry, Changsha 410004, China. Direct inquiries to author Zhu (E-mail address: zhuhl@nju.edu.cn).
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  • Qing-Shan Li,

    1. Authors Fu, X-W Zhang, Liu, Q-S Li, L-R Zhang, Yang, Z-M Zhang, Luo, He, Zhu are with State Key Lab. of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univ., Nanjing 210093, China. Author C-Z Li is with Hu’nan Academy of Forestry, Changsha 410004, China. Direct inquiries to author Zhu (E-mail address: zhuhl@nju.edu.cn).
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  • Li-Rong Zhang,

    1. Authors Fu, X-W Zhang, Liu, Q-S Li, L-R Zhang, Yang, Z-M Zhang, Luo, He, Zhu are with State Key Lab. of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univ., Nanjing 210093, China. Author C-Z Li is with Hu’nan Academy of Forestry, Changsha 410004, China. Direct inquiries to author Zhu (E-mail address: zhuhl@nju.edu.cn).
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  • Xian-Hui Yang,

    1. Authors Fu, X-W Zhang, Liu, Q-S Li, L-R Zhang, Yang, Z-M Zhang, Luo, He, Zhu are with State Key Lab. of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univ., Nanjing 210093, China. Author C-Z Li is with Hu’nan Academy of Forestry, Changsha 410004, China. Direct inquiries to author Zhu (E-mail address: zhuhl@nju.edu.cn).
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  • Zhi-Ming Zhang,

    1. Authors Fu, X-W Zhang, Liu, Q-S Li, L-R Zhang, Yang, Z-M Zhang, Luo, He, Zhu are with State Key Lab. of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univ., Nanjing 210093, China. Author C-Z Li is with Hu’nan Academy of Forestry, Changsha 410004, China. Direct inquiries to author Zhu (E-mail address: zhuhl@nju.edu.cn).
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  • Chang-Zhu Li,

    1. Authors Fu, X-W Zhang, Liu, Q-S Li, L-R Zhang, Yang, Z-M Zhang, Luo, He, Zhu are with State Key Lab. of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univ., Nanjing 210093, China. Author C-Z Li is with Hu’nan Academy of Forestry, Changsha 410004, China. Direct inquiries to author Zhu (E-mail address: zhuhl@nju.edu.cn).
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  • Yin Luo,

    1. Authors Fu, X-W Zhang, Liu, Q-S Li, L-R Zhang, Yang, Z-M Zhang, Luo, He, Zhu are with State Key Lab. of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univ., Nanjing 210093, China. Author C-Z Li is with Hu’nan Academy of Forestry, Changsha 410004, China. Direct inquiries to author Zhu (E-mail address: zhuhl@nju.edu.cn).
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  • Zhen-Xiang He,

    1. Authors Fu, X-W Zhang, Liu, Q-S Li, L-R Zhang, Yang, Z-M Zhang, Luo, He, Zhu are with State Key Lab. of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univ., Nanjing 210093, China. Author C-Z Li is with Hu’nan Academy of Forestry, Changsha 410004, China. Direct inquiries to author Zhu (E-mail address: zhuhl@nju.edu.cn).
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  • Hai-Liang Zhu

    1. Authors Fu, X-W Zhang, Liu, Q-S Li, L-R Zhang, Yang, Z-M Zhang, Luo, He, Zhu are with State Key Lab. of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing Univ., Nanjing 210093, China. Author C-Z Li is with Hu’nan Academy of Forestry, Changsha 410004, China. Direct inquiries to author Zhu (E-mail address: zhuhl@nju.edu.cn).
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  • Author disclosures: The material is original and has not been submitted for publication elsewhere. There is no conflict of interest in the manuscript. The main research in animal experiment, constituent analysis, docking study, data analysis, and article writing were finished by Jie Fu (1st author). Xue-Wei Zhang (2nd author) contributed in constituent analysis. Kai Liu (3rd author) and Qing-Shan Li (4th author) contributed in docking study. Li-Rong Zhang (5th author), Xian-Hui Yang (6th author) and Zhi-Ming Zhang (7th author) participated in animal experiment and constituent analysis. Yin Luo (9th author) contributed to the revision of the manuscript. Chang-Zhu Li (8th author) and Zhen-Xiang He (co-corresponding author) provided the oil sample, experimental conditions, and financial support. Hai-Liang Zhu (corresponding author) designed and directed the experiments.

Abstract

Abstract:  Cornus wilsoniana Wanger is a woody oil plant distributed in the south region of the Yellow River, China. Its oil has been taken as edible oil for over 100 y, and consumption of such oil is believed to prevent hyperlipidemia in Chinese folk recipe. This study has investigated the hypolipidemic effect of Cornus wilsoniana oil (CWO) in Sprague–Dawley rats. The results demonstrated that CWO could significantly decrease total cholesterol (TC), total triacylglycerol (TG), and low-density lipoprotein cholesterol (HDL-C) in serum, liver weight, hepatic TC, and TG. After analyzing the chemical constituents of CWO, we found that the content of unsaturated fatty acids (UFA) was very high (69.12%). Specially, the n-6 polyunsaturated fatty acids (PUFA), including linoleic acid, γ-linolenic acid, and 11,14-eicosadienoic acid, accounted very great proportion (38.86%). The high hypolipidemic activity of CWO might be attributed to the lipid-lowering functions of these polyunsaturated fatty acids. Molecular docking was further performed to study the binding model of fatty acids (FA) from CWO to a possible hypolipidemic target, peroxisome proliferator-activated receptor δ (PPARδ). The results showed that linoleic acid and γ-linolenic acid could bind PPARδ very well.

Practical Application:  Cornus wilsoniana oil could be used as equilibrated dietary oil, not only having hypolipidemic function, but also helping to overcome essential fatty acids deficiency.

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