Alpha-Lipoic Acid Protects against Indomethacin-Induced Gastric Oxidative Toxicity by Modulating Antioxidant System

Authors

  • Kursat Ali Kaplan,

    1. Authors Kaplan, Odabasoglu, Atalay, and Aydin are with the Dept. of Biochemistry, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Zekai Halici is with the Dept. of Pharmacology, Faculty of Medicine, Ataturk Univ., 25240 Erzurum, Turkey. Author Mesut Halici is with the Dept. of Biochemistry, Faculty of Veterinary, Ataturk Univ., 25240 Erzurum, Turkey. Author Cadirci is with the Dept. of Pharmacology, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Cakir is with the Dept. of Chemistry, Faculty of Science and Art, Kilis 7 Aralık Univ., 79000 Kilis, Turkey. Direct inquiries to author Cakir (E-mail: acakir@kilis.edu.tr; ahmedcakir@yahoo.com).
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  • Fehmi Odabasoglu,

    1. Authors Kaplan, Odabasoglu, Atalay, and Aydin are with the Dept. of Biochemistry, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Zekai Halici is with the Dept. of Pharmacology, Faculty of Medicine, Ataturk Univ., 25240 Erzurum, Turkey. Author Mesut Halici is with the Dept. of Biochemistry, Faculty of Veterinary, Ataturk Univ., 25240 Erzurum, Turkey. Author Cadirci is with the Dept. of Pharmacology, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Cakir is with the Dept. of Chemistry, Faculty of Science and Art, Kilis 7 Aralık Univ., 79000 Kilis, Turkey. Direct inquiries to author Cakir (E-mail: acakir@kilis.edu.tr; ahmedcakir@yahoo.com).
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  • Zekai Halici,

    1. Authors Kaplan, Odabasoglu, Atalay, and Aydin are with the Dept. of Biochemistry, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Zekai Halici is with the Dept. of Pharmacology, Faculty of Medicine, Ataturk Univ., 25240 Erzurum, Turkey. Author Mesut Halici is with the Dept. of Biochemistry, Faculty of Veterinary, Ataturk Univ., 25240 Erzurum, Turkey. Author Cadirci is with the Dept. of Pharmacology, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Cakir is with the Dept. of Chemistry, Faculty of Science and Art, Kilis 7 Aralık Univ., 79000 Kilis, Turkey. Direct inquiries to author Cakir (E-mail: acakir@kilis.edu.tr; ahmedcakir@yahoo.com).
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  • Mesut Halici,

    1. Authors Kaplan, Odabasoglu, Atalay, and Aydin are with the Dept. of Biochemistry, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Zekai Halici is with the Dept. of Pharmacology, Faculty of Medicine, Ataturk Univ., 25240 Erzurum, Turkey. Author Mesut Halici is with the Dept. of Biochemistry, Faculty of Veterinary, Ataturk Univ., 25240 Erzurum, Turkey. Author Cadirci is with the Dept. of Pharmacology, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Cakir is with the Dept. of Chemistry, Faculty of Science and Art, Kilis 7 Aralık Univ., 79000 Kilis, Turkey. Direct inquiries to author Cakir (E-mail: acakir@kilis.edu.tr; ahmedcakir@yahoo.com).
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  • Elif Cadirci,

    1. Authors Kaplan, Odabasoglu, Atalay, and Aydin are with the Dept. of Biochemistry, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Zekai Halici is with the Dept. of Pharmacology, Faculty of Medicine, Ataturk Univ., 25240 Erzurum, Turkey. Author Mesut Halici is with the Dept. of Biochemistry, Faculty of Veterinary, Ataturk Univ., 25240 Erzurum, Turkey. Author Cadirci is with the Dept. of Pharmacology, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Cakir is with the Dept. of Chemistry, Faculty of Science and Art, Kilis 7 Aralık Univ., 79000 Kilis, Turkey. Direct inquiries to author Cakir (E-mail: acakir@kilis.edu.tr; ahmedcakir@yahoo.com).
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  • Fadime Atalay,

    1. Authors Kaplan, Odabasoglu, Atalay, and Aydin are with the Dept. of Biochemistry, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Zekai Halici is with the Dept. of Pharmacology, Faculty of Medicine, Ataturk Univ., 25240 Erzurum, Turkey. Author Mesut Halici is with the Dept. of Biochemistry, Faculty of Veterinary, Ataturk Univ., 25240 Erzurum, Turkey. Author Cadirci is with the Dept. of Pharmacology, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Cakir is with the Dept. of Chemistry, Faculty of Science and Art, Kilis 7 Aralık Univ., 79000 Kilis, Turkey. Direct inquiries to author Cakir (E-mail: acakir@kilis.edu.tr; ahmedcakir@yahoo.com).
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  • Ozlem Aydin,

    1. Authors Kaplan, Odabasoglu, Atalay, and Aydin are with the Dept. of Biochemistry, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Zekai Halici is with the Dept. of Pharmacology, Faculty of Medicine, Ataturk Univ., 25240 Erzurum, Turkey. Author Mesut Halici is with the Dept. of Biochemistry, Faculty of Veterinary, Ataturk Univ., 25240 Erzurum, Turkey. Author Cadirci is with the Dept. of Pharmacology, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Cakir is with the Dept. of Chemistry, Faculty of Science and Art, Kilis 7 Aralık Univ., 79000 Kilis, Turkey. Direct inquiries to author Cakir (E-mail: acakir@kilis.edu.tr; ahmedcakir@yahoo.com).
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  • Ahmet Cakir

    1. Authors Kaplan, Odabasoglu, Atalay, and Aydin are with the Dept. of Biochemistry, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Zekai Halici is with the Dept. of Pharmacology, Faculty of Medicine, Ataturk Univ., 25240 Erzurum, Turkey. Author Mesut Halici is with the Dept. of Biochemistry, Faculty of Veterinary, Ataturk Univ., 25240 Erzurum, Turkey. Author Cadirci is with the Dept. of Pharmacology, Faculty of Pharmacy, Ataturk Univ., 25240 Erzurum, Turkey. Author Cakir is with the Dept. of Chemistry, Faculty of Science and Art, Kilis 7 Aralık Univ., 79000 Kilis, Turkey. Direct inquiries to author Cakir (E-mail: acakir@kilis.edu.tr; ahmedcakir@yahoo.com).
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Abstract

Abstract:  Gastroprotective effects of α-lipoic acid (ALA) against oxidative gastric damage induced by indomethacin (IND) have been investigated. All doses (50, 75, 100, 150, 200, and 300 mg/kg body weight) of ALA reduced the ulcer index with 88.2% to 96.1% inhibition ratio. In biochemical analyses of stomach tissues, ALA administration decreased the level of lipid peroxidation (LPO) and activities of myeloperoxidase (MPO) and catalase (CAT) in gastric tissues, which were increased after IND application. ALA also increased the level of glutathione (GSH) and activities of superoxide dismutase (SOD) and glutathione S-transferase (GST) that were decreased in gastric damaged stomach tissues. In conclusion, the gastroprotective effect of ALA could be attributed to its ameliorating effect on the antioxidant defense systems.

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