T: TOXICOLOGY AND CHEMICAL FOOD SAFETY
Safety Evaluation of Excessive Ingestion of Mozuku Fucoidan in Human
Article first published online: 6 MAR 2013
© 2013 Institute of Food Technologists®
Journal of Food Science
Volume 78, Issue 4, pages T648–T651, April 2013
How to Cite
Abe, S., Hiramatsu, K., Ichikawa, O., Kawamoto, H., Kasagi, T., Miki, Y., Kimura, T. and Ikeda, T. (2013), Safety Evaluation of Excessive Ingestion of Mozuku Fucoidan in Human. Journal of Food Science, 78: T648–T651. doi: 10.1111/j.1750-3841.2012.02966.x
- Issue published online: 5 APR 2013
- Article first published online: 6 MAR 2013
- Manuscript Accepted: 23 AUG 2012
- Manuscript Received: 29 FEB 2012
- excessive ingestion;
Fucoidan is a sulfated polysaccharide in the brown sea algae. This study was conducted in 20 subjects taking excessive fucoidan up to 4.05 g daily for 2 wk. They recorded questionnaire sheets about their health. Blood and urine were collected before and after 2 wk of ingestion. We found that no disorder was apparent in the test period. Although total cholesterol (P value 0.017) and low-density lipoprotein cholesterol (P value 0.017) showed statistically significant reduction and Cl (P value 0.002) showed significant increase, nothing deviated from the range of normal values. In conclusion, this study showed no abnormalities in the abdominal, fecal states, blood and urine at all.
This study showed no abnormality in the abdominal and fecal states when 20 healthy volunteers ingested excessive Mozuku fucoidan of around 4 g daily for 2 wk. Although total cholesterol and LDL-cholesterol showed statistically significant reduction and Cl showed significant increase, nothing deviated from the range of normal values. There were no laboratory abnormalities in the blood and urine at all.