Nitrites Derived From Foneiculum Vulgare (Fennel) Seeds Promotes Vascular Functions
Article first published online: 13 DEC 2012
© 2012 Institute of Food Technologists®
Journal of Food Science
Volume 77, Issue 12, pages H273–H279, December 2012
How to Cite
Swaminathan, A., Sridhara, S. R. C., Sinha, S., Nagarajan, S., Balaguru, U. M., Siamwala, J. H., Rajendran, S., Saran, U. and Chatterjee, S. (2012), Nitrites Derived From Foneiculum Vulgare (Fennel) Seeds Promotes Vascular Functions. Journal of Food Science, 77: H273–H279. doi: 10.1111/j.1750-3841.2012.03000.x
- Issue published online: 13 DEC 2012
- Article first published online: 13 DEC 2012
- MS 20120757 Submitted 5/30/2012, Accepted 9/28/2012.
- functional food;
- plant extract;
- vascular function
Abstract: Recent evidence has demonstrated that nitrites play an important role in the cardiovascular system. Fennel (Foneiculum vulgare) seeds are often used as mouth fresheners after a meal in both the Indian sub-continent and around the world. The present study aims to quantify the nitrite and nitrates in fennel seeds as well as elucidating the effect of fennel derived-nitrites on vascular functions. Results from our study show that fennel seeds contain significantly higher amount of nitrites when compared to other commonly used post-meal seeds. Furthermore our study confirmed the functional effects of fennel derived-nitrites using in vitro and ex vivo models that describe the promotion of angiogenesis, cell migration, and vasorelaxation. We also showed that chewing fennel seeds enhanced nitrite content of saliva. Thus our study indicates the potential role of fennel derived-nitrites on the vascular system.
Practical Application: This study is focused on determining the effect of fennel-derived nitrites on angiogenesis (the formation of new blood vessels from pre-existing ones), cell migration, and vasorelaxation (dilation of blood vessels) thereby preserving cardiovascular health.