TREATMENT OF EQUINE PHYCOMYCOSIS BY IMMUNOTHERAPY AND SURGERY
Version of Record online: 10 MAR 2008
Australian Veterinary Journal
Volume 57, Issue 8, pages 377–382, August 1981
How to Cite
Miller, R. I. (1981), TREATMENT OF EQUINE PHYCOMYCOSIS BY IMMUNOTHERAPY AND SURGERY. Australian Veterinary Journal, 57: 377–382. doi: 10.1111/j.1751-0813.1981.tb00526.x
- Issue online: 10 MAR 2008
- Version of Record online: 10 MAR 2008
- Accepted for publication 15 May 1981
SUMMARY: Treatment of equine phycomycosis with a vaccine derived from ultrasonicated hyphae of Hyphomyces destruens was attempted in 30 cases of clinical hyphomycosis, 10 cases of hyphomycosis following unsuccessful surgery and 5 cases of basidiobolomycosis. Approximately 53% of animals with clinical hyphomycosis were cured after vaccination, while a further 33% clinically improved. All horses with hyphomycosis treated within 2 weeks of unsuccessful surgery were cured. There was no response to vaccination with a Hyphomyces preparation in horses with basidiobolomycosis, while surgery alone resulted in a cure of approximately 69%.
Animals tolerated the vaccination procedures well. In all cases there was a moderate to severe reaction at the site of subcutaneous injection which subsided within 96 hours. In approximately 30% of injections a sterile abscess formed at the site but responded promptly to treatment. Response to vaccination at the site of the lesion was observed within 7 to 10 days of first injection. There was progressive reduction of pruritus, drying of the surface of the lesion, expulsion of kunkers, fibrosis of the granuloma, and eventually complete epithelialisation.