Antemortem diagnosis and treatment of toxoplasmosis in two cats on cyclosporin therapy
Article first published online: 1 JUN 2007
Australian Veterinary Journal
Volume 84, Issue 1-2, pages 30–35, January 2006
How to Cite
BARRS, V., MARTIN, P. and BEATTY, J. (2006), Antemortem diagnosis and treatment of toxoplasmosis in two cats on cyclosporin therapy. Australian Veterinary Journal, 84: 30–35. doi: 10.1111/j.1751-0813.2006.tb13119.x
- Issue published online: 1 JUN 2007
- Article first published online: 1 JUN 2007
- Accepted for publication 13 July 2005
Clinical toxoplasmosis was diagnosed antemortem in two cats being treated with therapeutic doses of cyclosporin. The diagnosis was made by detecting tachyzoites on cytological examination of bronchoalveolar lavage fluid from one case and pleural effusion from the other. Despite early diagnosis and aggressive treatment in both cases, only one cat survived. Reactivation of latent Toxoplasma gondii infection secondary to cyclosporin-induced immunosuppression was considered likely in both cases. The presence of respiratory signs in cats treated with cyclosporin should alert clinicians to the possibility of clinical toxoplasmosis. Consideration should be given to determining the serostatus of cats to T gondii prior to use of drugs which are potent inhibitors of cell mediated immunity such as cyclosporin.
Two cases of feline toxoplasmosis are presented.