PHOTOSENSITIZATION OF MELANINS: A COMPARATIVE STUDY

Authors

  • T. Sarna,

    1. National Biomedical ESR Center, Department of Radiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
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    • †On leave from the Institute of Molecular Biology, Jagiellonian University Department of Biophysics, Krakow, Poland.

  • I. A. Menon,

    1. Clinical Science Division, Medical Sciences Building, University of Toronto, Toronto, Canada
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  • Roger C. Sealy

    Corresponding author
    1. National Biomedical ESR Center, Department of Radiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
      *To whom correspondence should be addressed.
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*To whom correspondence should be addressed.

Abstract

Abstract— Measurements of photosensitized free-radical production and oxygen consumption have been made in several melanin systems. The melanins studied were cysteinyldopa melanin (a model for pheomelanin), natural pheomelanins extracted from red hair and from red chicken feathers, and eumelanin extracted from bovine eyes. Rose Bengal was used as photosensitizer. A significant enhancement in the rates of free radical production and oxygen consumption was found in all systems when sensitizer was present. The largest effects were found with cysteinyldopa melanin and effects on pheomelanins were shown to be greater (by factors of4–6) than on eumelanins.

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