Abstract— The sunburn cell (SC) is a type of individual cell death appearing in epidermis principally after exposure to middle-wavelength UV radiation (UVR). Because SCs can easily be recognized by histologic characteristics, they may provide a countable index of assessment of the degree of UVR injuries. However, despite extensive investigations, the mode of formation of this UVR-induced apoptosis has not fully been understood. In this review article, we are summarizing the results of recent studies with special reference to both the formation mechanisms and their implications in the field of photobiology.