THE DOSE-RESPONSE RELATIONSHIP OF TUMORIGENESIS BY ULTRAVIOLET RADIATION OF 254 nm

Authors

  • H. J. C. M. Sterenborg,

    Corresponding author
    1. Institutes of Dermatology, State University of Utrecht, Catharyne Singel 101,NL–3511 GV, Utrecht, The Netherlands
      *To whom correspondence should be addressed.
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  • S. C. J. van der Putte,

    1. Pathology, State University of Utrecht, Catharyne Singel 101,NL–3511 GV, Utrecht, The Netherlands
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  • J. C. van der Leun

    1. Institutes of Dermatology, State University of Utrecht, Catharyne Singel 101,NL–3511 GV, Utrecht, The Netherlands
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*To whom correspondence should be addressed.

Abstract

Abstract— Groups of albino hairless mice, Skh-hrl, were exposed daily to UVC radiation from low pressure Hg arcs (Philips TUV 40W). These lamps emit predominantly radiation of 254 nm. Three groups of animals were used in the experiments, each receiving a different daily dose.

The results were described with the Weibull probability function. As in earlier studies with UVB. the tumor induction time was proportional to a power of the daily dose. The exponent turned out to be as low as -0.2. This implies that the induction time varied only a little with the daily dose. The average number of tumors per animal was proportional to a power of time. A sample of 73 tumors of at least 4 mm in diameter were investigated histologically. The large majority were classified as squamous cell carcinomas.

A comparison was made with the results of an earlier reported experiment with Westinghouse FS40 sunlamps. Throughout the whole range of daily doses used in the present experiment, UVC was less carcinogenic than UVB. An intriguing difference between the two types of radiation was that the tumors induced by UVC appeared much more scattered over the irradiated parts of the animals than the UVB-induced tumors.

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