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GLUCOSE ADMINISTRATION AUGMENTS IN VIVO UPTAKE AND PHOTOTOXICITY OF THE TUMOR-LOCALIZING FRACTION OF HEMATOPORPHYRIN DERIVATIVE

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Abstract

Abstract Rhabdomyosarcoma tumors in rats made hyperglycemic by multiple injections of glucose exhibited a transient decrease in pH and an increased ability to accumulate derivatives of hemato-porphyrin (HPD). Photoradiation of tumors in glucose/HPD-treated animals produced a greater cell kill than in galactose/HPD-treated controls. A therapeutic benefit of glucose administration in conjunction with HPD-phototherapy is suggested.

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