*Division of Biomedical Research, Lovelace Research Foundation, Albuquerque, NM 87108, USA.
DO PYRIMIDINE DIMER YIELDS CORRELATE WITH ERYTHEMA INDUCTION IN HUMAN SKIN IRRADIATED in situ WITH ULTRAVIOLET LIGHT (275–365 nm)?
Article first published online: 2 JAN 2008
Photochemistry and Photobiology
Volume 53, Issue 4, pages 559–563, April 1991
How to Cite
HACHAM, H., FREEMAN, S. E., GANGE, R. W., MAYTUM, D. J., SUTHERLAND, J. C. and SUTHERLAND, B. M. (1991), DO PYRIMIDINE DIMER YIELDS CORRELATE WITH ERYTHEMA INDUCTION IN HUMAN SKIN IRRADIATED in situ WITH ULTRAVIOLET LIGHT (275–365 nm)?. Photochemistry and Photobiology, 53: 559–563. doi: 10.1111/j.1751-1097.1991.tb03671.x
- Issue published online: 2 JAN 2008
- Article first published online: 2 JAN 2008
- Received 12 September 1990; accepted 12 November 1990
Ultraviolet radiation produces erythema in human skin, and damages the DNA of living cells in skin. Previous work showed that broad-band UV-B (290–320 nm) radiation produced higher levels of cyclobutyl pyrimidine dimers in DNA of individuals with high UV-B sensitivity (low minimal erythema dose) than in subjects of low UV-B sensitivity [Freeman et al. (1986) J. Invest. Dermatol., 86, 34–36]. We examined the relationship between erythema induction and dimer yields in DNA of human skin irradiated in situ with narrow band radiation spanning the wavelength range 275–365 nm. We find that, in general, higher dimer yields are produced per incident photon in volunteers with higher susceptibility to erythema induced by radiation of the same wavelength.