Optical Doppler Tomography: Imaging in vivo Blood Flow Dynamics Following Pharmacological Intervention and Photodynamic Therapy

  1. Zhongping Chen*,
  2. Thomas E. Milner,
  3. Xiaojun Wang,
  4. Shyam Srinivas,
  5. J. Stuart Nelson

Article first published online: 2 JAN 2008

DOI: 10.1111/j.1751-1097.1998.tb05165.x

Issue

Photochemistry and Photobiology

Photochemistry and Photobiology

Volume 67, Issue 1, pages 56–60, January 1998

Additional Information

How to Cite

Chen, Z., Milner, T. E., Wang, X., Srinivas, S. and Nelson, J. S. (1998), Optical Doppler Tomography: Imaging in vivo Blood Flow Dynamics Following Pharmacological Intervention and Photodynamic Therapy. Photochemistry and Photobiology, 67: 56–60. doi: 10.1111/j.1751-1097.1998.tb05165.x

Author Information

  1. Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA, USA

* *To whom correspondence should be addressed at: Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA 92612, USA. Fax: 714-824-8413; e-mail: zchen@bli.uci.edu

Publication History

  1. Issue published online: 2 JAN 2008
  2. Article first published online: 2 JAN 2008
  3. Received 15 April 1997; accepted 8 August 1997

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ABSTRACT

A noninvasive optical technique has been developed for imaging in vivo blood flow dynamics and vessel structure with high spatial resolution. The technique is based on optical Doppler tomography, which combines Doppler velocimetry with optical coherence tomography to measure blood flow velocity at discrete spatial locations in turbid biological tissue. Applications of this technique for monitoring changes in blood flow dynamics and vessel structure following pharmacological intervention and photodynamic therapy are demonstrated.

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