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REFERENCES

  • 1
    Gannon, M. J. and S. B. Brown (1999) Photodynamic therapy and its applications in gynaecology. Br. J. Obs. Gynae. 106, 12461254.
  • 2
    Peng, Q., K. Berg, J. Moan, M. Kongshaug and J. M. Nesland (1997) 5–Aminolevulinic acid-based photodynamic therapy: principles and experimental research. Photochem. Photobiol. 65, 235251.
  • 3
    de Rosa, F. S. and M. V. L. B. Bentley (2000) Photodynamic therapy of skin cancers: sensitizers, clinical studies and future directives. Pharm. Res. 17, 14471455.
  • 4
    Fritsch, C., K. Lang, W. Neuse, T. Ruzicka and P. Lehmann (1998) Photodynamic diagnosis and therapy in dermatology. Skin Pharmacol. Appl. Skin Phys. 11, 358373.
  • 5
    Daniell, M. D. and J. S. Hill (1991) A history of photodynamic therapy. Austral. New Zeal. J. Surg. 61, 340348.
  • 6
    Moan, J. and Q. Peng (2003) An outline of the hundred-year history of PDT. Anticancer Res. 23, 35913600.
  • 7
    Henderson, B. W. and T. J. Dougherty (1992) How does photodynamic therapy work Photochem. Photobiol. 55, 145157.
  • 8
    Kennedy, J. C., R. H. Pottier and D. C. Pross (1990) Photodynamic therapy with endogenous protoporphyrin IX: basic principals and present clinical experience. J. Photochem. Photobiol. B: Biol. 6, 143148.
  • 9
    Kalka, K., H. Merk and H. Mukhtar (2000) Photodynamic therapy in dermatology. J. Am. Acad. Dermatol. 42, 389413.
  • 10
    Konan, Y. N., R. Gurny and E. Allemann (2002) State of the art in the delivery of photosensitizers for photodynamic therapy. J. Photochem. Photobiol. B: Biol. 66, 89106.
  • 11
    Dougherty, T. J., C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan and Q. Peng (1998) Photodynamic therapy. J. Nat. Cancer Inst. 90, 889905.
  • 12
    Kalyanasundaram, K. (1992) Photochemistry of Polypyridine and Porphyrin Complexes. Academic Press, London .
  • 13
    Isaacs, N. S. (1992) Physical Organic Chemistry. Longman Scientific and Technical, Essex , UK .
  • 14
    Oschner, M. (1997) Photophysical and photobiological processes in the photodynamic therapy of tumours. J. Photochem. Photobiol. B: Biol. 39, 118.
  • 15
    Moan, J., G. Streckyte, S. Bagdonas, O. Bech and K. Berg (1997) Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulinic acid. Int. J. Cancer 70, 9097.
  • 16
    Moan, J. (1990) On the diffusion length of singlet oxygen in cells and tissues. J. Photochem. Photobiol. B: Biol. 6, 343347.
  • 17
    Govil, S. K. (1988) Transdermal drug delivery systems. In Drug Delivery Devices (Edited byP.Tyle), Chapter 3. Marcel Dekker, New York .
  • 18
    Caimduff, F., M. R. Stringer, E. J. Hudson, D. V. Ash and S. B. Brown (1994) Superficial photodynamic therapy with topical 5-aminolevulinic acid for superficial primary and secondary cancer. Br. J. Cancer 69, 605608.
  • 19
    Leunig, A., M. Mehlmann, C. Betz, H. Stepp, S. Arbogast, G. Grevers and R. Baumgartner (2001) Fluorescence staining of oral cancer using a topical application of 5-aminolevulinic acid: fluorescence micro scopic studies. J. Photochem. Photobiol. B: Biol. 60, 4449.
  • 20
    Fehr, M. K., R. Hornung, V. A. Schwarz, R. Simeon, U. Haller and P. Wyss (2001) Photodynamic therapy of vulvar intraepithelial neo plasia iii using topically applied 5-aminolevulinic acid. Gyn. Oncol. 80, 6266.
  • 21
    Calzavara-Pinton, P. G. (1995) Repetitive photodynamic therapy with topical 5-aminolevulinic acid as an appropriate approach to the routine treatment of superficial non-melanoma skin tumours. J. Photochem. Photobiol. B: Biol. 29, 5357.
  • 22
    Meijnders, P. J. N., W. M. Star, R. S. De Bruijn, A. D. Treurniet-Donker, M. J. M. Van Mierlo, S. J. M. Wijthoff, B. Naafs, H. Beerman and P. C. Levendag, (1996) Clinical results of photodynamic therapy for superficial skin malignancies or actinic keratosis using topical 5-aminolevulinic acid. Lasers Med. Sci. 11, 123131.
  • 23
    Dijkstra, A. T., I. M. L. Majoie, J. W. F. van Dongen, H. van Weelden and W. A. van Vloten (2001) Photodynamic therapy with violet light and topical 5-aminolevulinic acid in the treatment of actinic keratosis, Bowen's disease and basal cell carcinoma. Eur. Acad. Dermatol. Venereol. 15, 550554.
  • 24
    Eleouet, S., N. Rousset, J. Carre, L. Bourre, V. Vonarx, Y. Lajat, G. M. J. Beijersbergen Van Henegouwen and T. Patrice (2000) In vitro fluorescence, toxicity and photoxicity induced by 5-amino levulinic acid (ala) or esters. Photochem. Photobiol. 71, 447454.
  • 25
    Gantchev, T. G., N. Brasseur and J. E. Van Lier (1996) Combination toxicity of etoposide (VP-16) and photosensitisation with water-soluble aluminium phthalocyanine in k562 human leukemic cells. Br. J. Cancer 74, 15701577.
  • 26
    Kessel, D. (1999) Transport and localisation of m-THPC in vitro. Int. J. Clin. Pract. 53, 263267.
  • 27
    Pottier, R. and J. C. Kennedy (1990) New trends in photobiology. The possible role of ionic species in selective biodistribution of photochemotherapeutic agents toward neoplastic tissue. J. Photochem. Photobiol. B: Biol. 8, 116.
  • 28
    Jori, G., M. Beltramini, E. Reddi, B. Salvato, A. Pagnan, L. Ziron, L. Tomio and T. Tsanov (1984) Evidence for a major role of plasma lipoproteins as haematoporphyrin carriers in vivo. Cancer Lett. 24, 291297.
  • 29
    Vaupel, P., F. Kallinowski and P. Okunieff (1989) Blood flow, oxygen and nutrient and metabolic microenvironment and human tumour. Cancer Res. 49, 64496465.
  • 30
    Kennedy, J. C., S. L. Marcus and R. H. Pottier (1996) Photodynamic therapy (PDT) and photodiagnosis (PD) using endogenous photosensitization induced by 5-aminolevulinic acid (ALA): mechanisms and clinical results. J. Clin. Laser Med. Surg. 14, 289304.
  • 31
    Kennedy, J. C. and R. H. Pottier (1992) Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy. J. Photochem. Photobiol. B: Biol 14, 275292.
  • 32
    Peng, Q., T. Warloe, K. Berg, J. Moan, M. Kongshaug K. E. Giercksky and J. M. Nesland (1997) 5-Aminolevulinic acid-based photodynamic therapy: clinical research and future challenges. Cancer 79, 22822308.
  • 33
    Berg, K., H. Anholt, O. Bech and J. Moan (1996) The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolevulinic acid-treated cells. Br. J. Cancer 74, 688697.
  • 34
    Rittenhouse-Diakun, K., H. Van Leengoed and J. Morgan (1995) The Role of Transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic acid (ALA) Photochem. Photobiol. 61, 523528.
  • 35
    Bottomley, S. and U. Muller-Eberhard (1988) Pathophysiology of heme synthesis. Sem. Heme Synth. 25, 282302.
  • 36
    Moan, J., K. Berg, O. Gadmar, V. Lani, L. W. Ma and P. Juzenas 1999) The temperature dependence of protoporphyrin IX production in cells and tissues. Photochem. Photobiol. 70, 669673.
  • 37
    Moan, J., J. T. H. M. Vanden Akker, P. Juzenas, L. W. Ma, E. Angell-Peterson, O. B. Gadmar and V. Iani (2001) On the basis for tumor selectivity in the 5-aminolevulinic acid-induced synthesis of protoporphyrin IX. J. Porph. Phthalocyan. 5, 170176.
  • 38
    Krieg, R. C., H. Messmann, J. Rauch, S. Seeger and R. Knuechel (2002) Metabolic characterization of tumor cell-specific protoporphyrin IX accumulation after exposure to 5-aminolevulinic acid in human colonic cells. Photochem. Photobiol. 76, 518525.
  • 39
    Gibson, S. L., J. J. Havens, L. Metz and R. Hilf (2001) Is delta-aminolevulinic acid dehydratase rate limiting in heme biosynthesis following exposure of cells to delta-aminolevulinic acid Photochem. Photobiol. 73, 312317.
  • 40
    Krieg, R. C., S. Fickweiler, S. Appel, O. S. Wolfbeis and R. Knuechel (2000) Cell-type specific protoporphyrin IX metabolism in human bladder cancer in vitro. Photochem. Photobiol. 72, 22633.
  • 41
    Jin, Z. H., N. Miyoshi, K. Ishiguro, K. Takaoka, T. Udagawa, H. Tajiri, K. Ueda, M. Fukuda and M. Kumakiri (2000) Photodynamic therapy based on combined use of 5-aminolevulinic acid with a pheophoride-a derivative for murine tumors. In Vivo 14, 529534.
  • 42
    Wong, T. W., K. Aizawa, I. Sheyhedin, C. Wushur and H. Kato (2003) Pilot study of topical delivery of mono-I-aspartyl chlorin e6 (NPe6): implication of topical npe6-photodynamic therapy. J. Pharmacol. Sci. 93, 136142.
  • 43
    Soler, A. M., T. Warloe, J. Tausjo and A. Berner (1999) Photodynamic therapy by topical aminolevulinic acid, dimethyl sulfoxide and curettage in nodular basal cell carcinoma: a one-year follow-up study. Acta Dermatol. Venereol. 79, 204206.
  • 44
    Jeffes, E. W., J. L. McCullough, G. P. Weinstein, P. E. Fergin, J. S. Nelson, T. F. Shull, K. R. Simpson, L. M. Bukaty, W. L. Hoffman and N. L. Fong (1997) Photodynamic therapy of actinic keratosis with topical 5-aminolevulinic acid: a pilot dose-ranging study. Arch. Dermatol. 133, 727732.
  • 45
    Svanberg, K., T. Andersson, D. Killander, D. Wang, U. Stenram, S. Andersson-Engels, R. Berg, J. Johansson and S. Svanberg (1994) Photodynamic therapy of non-melanoma malignant tumours of the skin using topical 5-aminolevulinic acid sensitization and laser irradiation. Br. J. Dermatol. 130, 743751.
  • 46
    Morton, C. A., C. Whitehurst, H. Moseley, J. H. McColl, J. V. Moore and R. M. Mackie (1996) Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease. Br. J. Dermatol. 135, 766771.
  • 47
    Morton, C. A., C. Whitehurst, J. V. Moore and R. M. MacKie (2000) Comparison of red and green light in the treatment of Bowen's disease by photodynamic therapy. Br. J. Dermatol. 143, 767772.
  • 48
    Martin-Hirsch, P. L., C. Whitehurst, C. H. Buckley, J. V. Moore and H. C. Kitchener (1998) Photodynamic treatment for lower genital tract intraepithelial neoplasia. Arch. Dermatol. 134, 247249.
  • 49
    Abdel-Hady, E. S., P. Martin-Hirsch, M. Duggan-Keen, P. L. Stern, J. V. Moore, G. Corbitt, H. C. Kitchner and I. N. Hampson (2001) Immunological and viral factors associated with the response of vulval intraepithelial neoplasia to photodynamic therapy. Cancer Res. 61, 192196.
  • 50
    Zawislak, A., P. A. McCarron, W. G. McCluggage, J. H. Price, R. F. Donnelly, R. H. McClelland, S. P. Dobbs and A. D. Woolfson (2004) Successful photodynamic therapy of vulval Paget's disease using a novel patch-based delivery system containing 5-aminolevulinic acid. Br. J. Obs. Gynae. 111, 13.
  • 51
    Wierrani, F., A. Kubin, R. Jindra, M. Henry, K. Gharehbaghi, W. Grin, J. Soltz-Szotz, G. Alth and W. Grunberger (1999) 5-Aminolevulinic acid-mediated photodynamic therapy of intraepithelial neoplasia and human papillomavirus of the uterine cervix-a new experimental approach. Cancer Detec. Prev. 23, 351355.
  • 52
    Novo, M., G. Huttmann and H. Diddens (1996) Chemical instability of 5-aminolevulinic acid used in the fluorescence diagnosis of bladder tumours. J. Photochem. Photobiol. B: Biol. 34, 143148.
  • 53
    Lange, N., P. Jichlinski, M. Zellweger, M. Forrer, A. Marti, L. Guillou, P. Kucera, G. Wagnieres and H. Van den Bergh (1999) Photodetection of early human bladder cancer based on the fluorescence of 5-aminolevulinic acid hexylester-induced protopor-phyrin IX. Br. J. Cancer 80, 185193.
  • 54
    Wyss-Desserich, M. T., C. H. Sun and P. Wyss (1996) Accumulation of 5-aminolevulinic acid-induced protoporphyrin ix in normal and neoplastic human endometrial epithelial cells. Biochem. Biophys. Res. Comm. 224, 819824.
  • 55
    Keefe, K. K., E. B. Chahine, P. J. DiSaia, T. B. Krasieva, F. Lin, M. W. Berns and Y. Tadir (2001) Fluorescence detection of cervical intraepithelial neoplasia for photodynamic therapy with the topical agents 5-aminolevulinic acid and benzoporphyrin-derivative mono-acid ring. Am. J. Obs. Gyn. 184, 11641169.
  • 56
    Hurlimann, A. F., G. Hanggi and R. G. Panizzon (1998) Photodynamic therapy of superficial basal cell carcinomas using topical 5-aminolevulinic acid in a nanocolloid lotion. Dermatology 197, 248254.
  • 57
    Lieb, S., R. M. Szeimies and G. Lee (2002) Self-adhesive thin films for topical delivery of 5-aminolevulinic acid. Eur. J. Pharm. Biopharm. 53, 99106.
  • 58
    Casas, A., H. Fukuda, G. Di Venosa, A. M. Del and C. Batlle (2000) The influence of the vehicle on the synthesis of porphyrins after topical application of 5-aminolevulinic acid. implications in cutaneous photodynamic sensitisation. Br. J. Dermatol. 143, 564572.
  • 59
    Malik, Z., G. Kostenich, L. Roitman, B. Ehrenberg and A. Orenstein (1995) Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin ix accumulation in skin and tumours of mice. J. Photochem. Photobiol. B: Biol. 28, 213218.
  • 60
    Soler, A. M., T. Warloe, A. Berner and K. E. Giercksky (2001) A follow-up study of recurrence and cosmesis in completely responding superficial and nodular basal cell carcinomas treated with methyl 5-aminolevulinate-based photodynamic therapy alone with prior curettage. Br. J. Dermatol. 145, 467471.
  • 61
    Morton, C. A., R. M. MacKie, C. Whitehurst, J. V. Moore and J. H. McColl (1998) Photodynamic therapy for basal cell carcinoma: effect of tumour thickness and duration of photosensitizer application on response. Arch. Dermatol. 134, 248249.
  • 62
    Moan, J., L. W. Ma and V. Iani (2001) On the pharmacokinetics of topically applied 5-aminolevulinic acid and two of its esters. Int. J. Cancer 92, 139143.
  • 63
    Fuchs, C., R. Riesenberg, J. Siegert and R. Baumgartner (1997) pH-dependent formation of 5-aminolevulinic acid-induced protoporphyrin IX in fibrosarcoma cells. J. Photochem. Photobiol. B: Biol. 40, 4954.
  • 64
    Xiang, W., H. Weingandt, F. Liebmann, S. Klein, H. Stepp, R. Baumgartner and P. Hillemanns (2001) Photodynamic effects induced by aminolevulinic acid esters on human cervical carcinoma cells in culture. Photochem. Photobiol. 74, 617623.
  • 65
    Van den Akker, J. T. H. M., V. Iani, W. M. Star, H. J. C. M. Sterenborg and J. Moan (2000) Topical application of 5-aminolevulinic acid hexyl ester and 5-aminolevulinic acid to normal nude mouse skin: differences in protoporphyrin ix fluorescence kinetics and the role of the stratum corneum. Photochem. Photobiol. 72, 681689.
  • 66
    Casas, A., H. Fukuda, A. M. Del and C. Batlle (1999) Tissue distribution and kinetics of endogenous porphyrins synthesized after topical application of ala in different vehicles. Br. J. Cancer 81, 1318.
  • 67
    Tsai, J. C., H. Chen, W. Wong and Y. L. Lo (2002) In vitro/in vivo correlations between transdermal delivery of 5-aminolevulinic acid and cutaneous protoporphyrin ix accumulation and effect of formulation. Br. J. Dermatol. 146, 853862.
  • 68
    Konig, K., A. Kienle, W. H. Boehncke, R. Kaufmann, A. Ruck T. Meier and R. Steiner (1994) Photodynamic tumour therapy and on-line fluorescence spectroscopy after ala administration using 633 nm light as therapeutic and fluorescence excitation radiation. Opt. Eng. 33, 29452953.
  • 69
    Szeimeis, R. M., T. Sassy and M. Landthaler (1994) Penetration potency of topical applied 5-aminolevulinic acid for photodynamic therapy of basal cell carcinoma. Photochem. Photobiol. 59, 7376.
  • 70
    Pahernik, S., S. Langer, A. Botzlar, M. Dellian and A. E. Goetz (2001) Tissue distribution and penetration of 5-ALA induced fluorescence in an amelanotic melanoma after topical application. Anticancer Res. 21, 5964.
  • 71
    Wennberg, A. M., O. Larko, P. Lonnroth, G. Larson and A. L. Krogstad (2000) 5-Aminolevulinic acid in superficial basal cell carcinomas and normal skin: a microdialysis and perfusion study. Clin. Exp. Dermatol. 25, 317322.
  • 72
    Ahmadi, S., P. A. McCarron, R. F. Donnelly, A. D. Woolfson and K. McKenna (2004) Evaluation of the penetration of 5-aminolevulinic acid through basal cell carcinoma: a pilot study. Exp. Dermatol. 13, 17.
  • 73
    McLoone, N., R. F. Donnelly, P. A. McCarron, M. Walsh and K. McKenna (2004) Aminolevulinic acid penetration into nodular basal cell carcinomas: influence of different concentrations and application times on amounts of ala delivered via a bioadhesive patch. Clin. Photodyn. 1, 56.
  • 74
    Johnson, P. G., S. W. Hui and A. R. Oseroff (2002) Electrically enhanced percutaneous delivery of 5-aminolevulinic acid using electric pulses and a dc potential. Photochem. Photobiol. 75, 534540.
  • 75
    Donnelly, R. F., P. A. McCarron, A. D. Woolfson, A. Zawislak and J. H. Price (2004) Autoradiographic imaging of 5-aminolevulinic acid penetration through vaginal tissue. Clin. Photodyn. 1, 67.
  • 76
    Duska, L. R., J. Wimberly, T. F. Deutsch, B. Ortel, J. Haas, K. Houck and T. Hasan (2002) Detection of female lower genital tract dysplasia using orally administered 5-aminolevulinic acid induced protoporphyrin IX: a preliminary study. Gyn. Oncol. 85, 125128.
  • 77
    Loh, C. S., A. J. MacRobert, A. Bedwell, J. Regula, N. Krasner and S. G. Bown (1993) Oral versus intravenous administration of 5-aminolevulinic acid for photodynamic therapy. Br. J. Cancer 68, 4151.
  • 78
    Webber, J., D. Kessel and D. Fromm (1997) Side effects and photosensitization of human tissues after aminolevulinic acid. J. Surg. Res. 68, 3137.
  • 79
    Herman, M. A., J. Webber, D. Fromm and D. Kessel (1998) Hemodynamic effects of 5-aminolevulinic acid. J. Photochem. Photobiol. B: Biol. 43, 6165.
  • 80
    Ackroyd, R., N. Brown, D. Vernon, D. Roberts, T. Stephenson, S. Marcus, C. Stoddard and M. Reed (1999) 5-Aminolevulinic acid photosensitization of dysplastic Barrett's oesophagus: a pharmacokinetic study. Photochem. Photobiol. 70, 656662.
  • 81
    McGillian, F. B., G. G. Thompson, M. R. Moore and A. Goldberg (1974) The passage of 5-aminolevulinic acid across the blood-brain barrier of the rat. Biochem. Pharmacol. 23, 472.
  • 82
    de Blois, A. W., M. R. T. M. Thissen, H. S. De Bruijn, R. J. E. Grouls, R. P. Dutrieux, D. J. Robinson and H. A. M. Neumann (2001) In vivo pharmacokinetics of protoporphyrin IX accumulation following intracutaneous injection of 5-aminolevulinic acid. J. Photochem. Photobiol. B: Biol. 61, 2129.
  • 83
    Thissen, M., M. W. De Blois, D. J. Robinson, H. S. De Bruijn, R. P. Dutrieux, W. M. Star and H. A. M. Neumann (2002) PpIX fluorescence kinetics and increased skin damage after intracutaneous injection of 5-aminolevulinic acid and repeated illumination. J. Inv. Dermatol. 118, 239245.
  • 84
    Woolfson, A. D. and D. F. McCafferty (1993) Percutaneous Local Anaesthesia. Ellis Horwood, London .
  • 85
    Peng, Q., T. Warloe, J. Moan, H. Heyerdahl, H. B. Steen, J. M. Nesland and K. E. Giercksky (1995) Distribution of 5-aminolevulinic acid-induced porphyrins in noduloulcerative basal-cell carcinoma. Photochem. Photobiol. 62, 906913.
  • 86
    Peng, Q., J. Moan, T. Warloe, V. Iani, H. B. Steen, A. Bjorseth and J. M. Nesland (1996) Build-up of esterified aminolevulinic acid derivative-induced porphyrin fluorescence in normal mouse skin. J. Photochem. Photobiol. B: Biol. 34, 9596.
  • 87
    Berger, Y., A. Greppi, O. Siri, R. Neier and L. Juillerat-Jeanneret (2000) Ethylene glycol and amino acid derivatives of 5-aminolevulinic acid as new photosensitising precursors of protoporphyrin ix in cells. J. Med. Chem. 43, 47384746.
  • 88
    Berger, Y., L. Ingrassia, R. Neier and L. Juillerat-Jeanneret (2003) Evaluation of dipeptide-derivatives of 5-aminolevulinic acid as precursors for photosensitisers in photodynamic therapy. Bioorg. Med. Chem. 11, 13411351.
  • 89
    Rick, K., R. Sroka, H. Stepp, M. Kreigmair, R. M. Huber, K. Jacob and R. Baumgartner (1997) Pharmacokinetics of 5-aminolevulinic acid-induced protoporphyrin ix in skin and blood. J. Photochem. Photobiol. B: Biol. 40, 313319.
  • 90
    Winkler, A. and C. C. Muller-Goymann (2002) Comparative permeation studies for 5-aminolevulinic acid and its n-butyl ester through stratum corneum and artificial skin constructs. Eur. J. Pharm. Biopharm. 53, 281287.
  • 91
    de Rosa, F. S., A. C. Tedesco, R. F. V. Lopez, M. B. R. Pierre, N. Lange, J. M. Marchetti, J. C. G. Rotta and M. V. L. B. Bentley (2003) In vitro permeation and retention of 5-aminolevulinic acid ester derivatives for photodynamic therapy. J. Cont. Rel. 89, 261269.
  • 92
    Van den Akker, J. T. H. M., J. A. Holroyd, D. I. Vernon, H. J. C. M. Sterenborg and S. B. Brown (2003) Comparative in vitro percutaneous penetration of 5-aminolevulinic acid and two of its esters through excised hairless mouse skin. Lasers Surg. Med. 33, 173181.
  • 93
    Gerscher, S., J. P. Connelly, J. Griffiths, S. B. Brown, A. J. MacRobert, G. Wong and L. E. Rhodes (2000) Comparison of the pharmacokinetics and phototoxicity of protoporphyrin ix metabolized from 5-aminolevulinic acid and two derivatives in human skin in vivo. Photochem. Photobiol. 72, 569574.
  • 94
    Gerscher, S., J. P. Connelly, G. M. J. Beijersbergen Van Henegouwen, A. J. MacRobert, P. Watt and L. E. Rhodes (2001) A quantitative assessment of protoporphyrin IX metabolism and phototoxicity in human skin following dose-controlled delivery of the prodrugs 5-aminolaevulinic acid and 5-aminolaevelunic acid-n-pentlyester. Br. J. Derm. 144, 983990.
  • 95
    Peng, Q., A. M. Soler, T. Warloe, J. M. Nesland and K. E. Giercksky (2001) Selective distribution of porphyrins in skin thick basal cell carcinoma after topical application of methyl 5-aminolevulinate. J. Photochem. Photobiol. B: Biol. 62, 140145.
  • 96
    Moan, J., L. W. Ma, A. Juzeniene, V. Iani, P. Juzenas, F. Apricena and Q. Peng (2003) Pharmacology of protoporphyrin IX in nude mice after application of ALA and its esters. Int. J. Cancer 103, 132135.
  • 97
    Juzeniene, A., P. Juzenas, V. Iani and J. Moan (2002) Topical application of 5-aminolevulinic acid and its methylester, hexylester and octylester derivatives: considerations for dosimetry in mouse skin model. Photochem. Photobiol. 76, 329334.
  • 98
    Lange, N., P. Jichlinski, M. Zellweger, M. Forrer, A. Marti, L. Guillou, P. Kucera, G. Wagnieres and H. Van den Bergh (1999) Photodetection of early human bladder cancer based on the fluorescence of 5-aminolevulinic acid hexylester-induced protoporphyrin IX. Br. J. Cancer 80, 185193.
  • 99
    Elliott, T. (1993) Transport of 5-aminolevulinic acid by the dipeptide permeasein Salmonella typhimurium. J. Bact. 175, 325331.
  • 100
    Verkamp, E., V. M. Backman, J. M. Bjornsson, D. Soil and G. Eggertsson (1993) The periplasmic dipeptide permease system transports 5-aminolevulinic acidin Escherichia coli. J. Bact. 175, 14521456.
  • 101
    Moretti, B. M., S. C. Garci, C. Stella, E. Ramos, A. M. Del and C. Batlle (1993) 5-Aminolevulinic acid transportin Saccharomyces cerevisiae. Int. J. Biochem. 25, 19171924.
  • 102
    Rud, E., O. Gederaas, A. Hogset and K. Berg (2000) 5-Aminolevulinic acid, but not 5-aminolevulinic acid esters, is transported into adenocarcinoma cells by system BETA transporters. Photochem. Photobiol. 71, 640647.
  • 103
    Whitaker, C. J., S. H. Battah, M. J. Forsyth, C. Edwards, R. W. Boyle and E. K. Matthews (2000) Photosensitisation of pancreatic tumour cells by delta-aminolaevulinic acid esters. Anticancer Drug Res. 15, 161170.
  • 104
    Doring, F., J. Walter, J. Will, M. Focking, M. Boll, S. Amasheh, W. Clauss and H. Daniel (1998) Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications. J. Clin. Invest. 101, 27612767.
  • 105
    Gederaas, O. A., A. Holroyd, S. B. Brown, D. Vernon, J. Moan and K. Berg (2001) 5-Aminolaevulinic acid methyl ester transport on amino acid carriers in a human colon adenocarcinoma cell line. Photochem. Photobiol. 73, 164169.
  • 106
    Lopez, R. F., N. Lange, R. H. Guy and M. V. L. B. Bentley (2004) Photodynamic therapy of skin cancer: controlled drug delivery of 5-ALA and its esters. Adv. Drug Del. Rev. 56, 7794.
  • 107
    Lange, N., L. Vaucher, A. Marti, A. L. Etter, P. Gerber, H. Van den Berg, P. Jichlinski and P. Kucera (2001) Routine experimental system for defining conditions used in photodynamic therapy and fluorescence photodetection of (non-) neoplastic epithelia. J. Biomed. Opt. 6, 151159.
  • 108
    Kloek, J. and M. J. Beijersbergen Van Henegouwen (1996) Prodrugs of 5-aminolevulinic acid for photodynamic therapy. Photochem. Photobiol. 64, 9941000.
  • 109
    Gaullier, J. M., K. Berg, Q. Peng, H. Anholt, P. K. Selbo, L. W. Ma and J. Moan (1997) Use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture. Cancer Res. 57, 14811486.
  • 110
    Uehlinger, P., M. Zellweger, G. Wagnieres, L. Juillerat-Jeanneret, H. Van den Bergh and N. Lange (2000) 5-Aminolevulinic acid and it's derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells. J. Photochem. Photobiol. B: Biol. 54, 7280.
  • 111
    Hausmann, F., R. C. Krieg, E. Endlicher, I. Resenberg, K. Ruth and H. Brunner (2001) The effects of 5-aminolevulinic acid (ALA)-esters on ALA-induced protoporphyrin (PpIX) production and localization in human adenocarcinoma cell lines. Gastroenterology 120, A618.
  • 112
    Bigelow, C. E., S. Mitra, R. Knuechel and T. H. Foster (2001) ALA and ALA-hexylester-induced protoporphyrin IX fluorescence and distribution in multicell tumor spheroids. Br. J. Cancer 85, 727734.
  • 113
    Szeimies, R. M., S. Karrer, S. Radakovic-Fijan, A. Tanew, P. G. Calzavara-Pinton, C. Zane, A. Sidoroff, M. Hempel, J. Ulrich, T. Proebstle, H. Meffert, M. Mulder, D. Salomon, H. C. Dittmar, J. W. Bauer, K. Kernland and L. Braathen (2002) Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: a prospective, randomized study. J. Am. Acad. Dermatol. 47, 258262.
  • 114
    Yamauchi, P. S., N. J. Lowe, G. P. Lask, R. Patnaik, D. Moore and P. Foley (2002) Methyl aminolevulinate and photodynamic therapy in the treatment of actinic keratosis. J. Invest. Dermatol. 119, 804.
  • 115
    Pearse, A. D. (2002) Applications for topical PDT: basal cell carcinomas. Photodyn. News 5, 15.
  • 116
    Zeitouni, N. C., A. R. Oseroff and S. Shieh (2003) Photodynamic therapy of nonmelanoma skin cancers. Current review and update. Mol. Immunol. 39, 11331136.
  • 117
    Harth, Y., B. Hirshowitz and B. Kaplan (1998) Modified topical photodynamic therapy of superficial skin tumours, utilizing aminolevulinic acid, penetration enhancers, red light and hyperthermia. J. Am. Soc. Dermatol. Surg. 24, 723726.
  • 118
    Auner, B. G., C. Valenta and J. Hadgraft (2003) Influence of lipophilic counter-ions in combination with phloretin and 6-Ketocholestanol on the skin permeation of 5-aminolevulinic acid. Int. J. Pharm. 255, 109116.
  • 119
    Barry, B. W. (1987) Mode of action of penetration enhancers in human skin. J. Cont. Rel. 6, 8597.
  • 120
    Barry, B. W. (1991) The LPP theory of skin penetration. In In vitro Percutaneous Absorption: Principles, Fundamentals and Applications (Edited byR. L.Bronaugh and H. I.Maibach), p. 165. CRC Press, Boca Raton , FL .
  • 121
    Barry, B. W. (1991) Lipid-protein-partitioning theory of skin penetration enhancement. J. Cont. Rel. 15, 237.
  • 122
    Goodman, M. and B. W. Barry (1989) Lipid-protein partitioning theory of skin enhancer activity: finite dose technique. Int. J. Pharm. 57, 29.
  • 123
    Allenby, A. C., N. H. Creasy, J. A. G. Edington, J. A. Fletcher and C. Schock (1969) Mechanism of action of accelerants on skin penetration. Br. J. Dermatol. 81, 4755.
  • 124
    Henderson, T. R., R. F. Henderson and J. L. York (1975) Biological Actions of Dimethyl Sulfoxide. Academic Science, New York .
  • 125
    Galbraith, R. A., S. Sassa and A. Kappas (1986) Induction of haem synthesis in Hep G2 human hepatoma cells by dimethyl sulfoxide. Biochem. J. 237, 597600.
  • 126
    Fujita, H., M. Yamamoto, T. Yamagami, N. Hayashi, T. R. Bishop, H. De Verneuil, T. Yoshinaga, S. Shibahara, R. Morimoto and S. Sassa (1991) Sequential activation of hemes for heme pathway enzymes during erythroid differentiation of mouse friend virus-transformed erythroleukemia cells. Biochim. Biophys. Acta 1090, 311316.
  • 127
    Kurihara-Bergstrom, T., G. L. Flynn and W. I. Higuchi (1987) Physiochemical study of percutaneous absorption enhancement by dimethyl sulfoxide: dimethyl sulfoxide mediation of vidarabine (ara-A) permeation of hairless mouse skin. J. Invest. Dermatol. 89, 274.
  • 128
    Kligman, A. M. (1965) Topical pharmacology and toxicology of dimethyl sulfoxide. JAMA. 193, 796.
  • 129
    Al-Saidan, S. M. H., A. B. Selkirk and A. J. Winfield (1987) Effect of dimethyl sulfoxide concentration on the permeability of neonatal rat stratum corneum to alkanols. J. Invest. Dermatol. 89, 426.
  • 130
    Kurihara-Bergstrom, T., G. L. Flynn and W. I. Higuchi (1986) Physiochemical study of percutaneous absorption enhancement by dimethyl sulfoxide: Kinetic and thermodynamic determinants of dimethyl sulfoxide-mediated mass transfer of alkanols. J. Pharm. Sci. 75, 479.
  • 131
    de Rosa, F. S., J. M. Marchetti, J. A. Thomazini, A. C. Tedesco, M. V. Lopes and B. Bentley (2000) A vehicle for photodynamic therapy of skin cancer: influence of dimethyl sulfoxide on 5-aminolevulinic acid in vitro cutaneous permeation and in vivo protoporphyrin ix accumulation determined by confocal microscopy. J. Cont. Rel. 65, 359366.
  • 132
    Steluti, R., F. S. De Rosa, J. H. Collett and M. V. L. B. Bentley (2001) In vitro skin retention and permeation studies for 5-aminolevulinic acid: effect of a lipid penetration enhancer. Eur. J. Pharm. Sci. 13, S132.
  • 133
    Williams, A. C. (2003) Transdermal and Topical Drug Delivery. Pharmaceutical Press, London .
  • 134
    Wolf, J. (1939) Die Innere Strucktur der Zellen des Stratum Desquamans der Menschlichen Epidermis. Anat. Forsch. 46, 170202.
  • 135
    Loveday, D. E. (1961) An in vitro model for studying percutaneous absorption. J. Soc. Cosm. Chem. 12, 224239.
  • 136
    Morton, C. A., C. Whitehurst, J. H. McColl, J. V. Moore and R. M. MacKie (2001) Photodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma. Arch. Dermatol. 137, 319324.
  • 137
    Centre for Cosmetic Dermatology (2004) Available at: http://www.drweksberg.com. Accessed 17 May 2004.
  • 138
    Levy, D., J. Kost, Y. Meshulam and R. Langer (1989) Effect of ultrasound on transdermal drug delivery to rats and guinea pigs. J. Clin. Invest. 83, 20742078.
  • 139
    Bomannan, D., G. K. Menon, H. Okuyama, P. M. Elias and R. H. Guy (1992) Sonophoresis II. Examination of the mechanism(s) of ultrasound-enhanced transdermal drug delivery. Pharm. Res. 9, 10431047.
  • 140
    Doukas, A. G. and T. J. Flotte (1996) Physical characteristics and biological effects of laser-induced stress waves. Ultrasound Med. Biol. 22, 151164.
  • 141
    Ter Haar, G. R. (1988) Biological effects of ultrasound in clinical applications. In Ultrasound: Its Chemical Physical Biological Effects (Edited byK. S.Suslick), pp. 305320. VCH, New York .
  • 142
    Doukas, A. G., D. J. McAuliffe, S. Lee, V. Venugopalan and T. J. Flotte (1995) Physical factors involved in stress-wave-induced cell injury: the effect of stress gradient. Ultrasound Med. Biol. 21, 961967.
  • 143
    Lee, S., T. Anderson, H. Zhang, T. J. Flotte and A. G. Doukas (1996) Alteration of cell membrane by stress waves in vitro. Ultrasound Med. Biol. 22, 12851293.
  • 144
    McAuliffe, D. J., S. Lee, T. J. Flotte and A. G. Doukas (1997) Stress-wave-assisted transport through the plasma membrane in vitro. Lasers Surg. Med. 20, 216222.
  • 145
    Lee, S., D. J. McAuliffe, H. Zhang, Z. Xu, J. Taitelbaum, T. J. Flotte and A. G. Doukas (1997) Stress-wave-induced membrane permeation of red blood cells is facilitated by water channels. Ultrasound Med. Biol. 23, 10891094.
  • 146
    Ma, L., J. Moan, Q. Peng and V. Iani (1998) Production of protoporphyrin IX induced by 5-aminolevulinic acid in transplanted human colon adenocarcinoma of nude mice can be increased by ultrasound. Int. J. Cancer 78, 464469.
  • 147
    Nyborg, W. L. (1982) Ultrasonic microstreaming and related phenomena. Brit. J. Cancer 45(Suppl. V), 156154.
  • 148
    Lee, S., A. Kollias, D. J. McAuliffe, T. J. Flotte and A. G. Doukas (1999) Topical drug delivery in humans with a single photomechanical wave. Pharm. Res. 16, 17171721.
  • 149
    Van den Akker, J. T. H. M., K. Boot, D. I. Vernon, S. B. Brown, L. Groenendijk, G. C. Van Rhoon and H. J. C. M. Sterenborg (2004) Effect of elevating the skin temperature during topical ALA application on in vitro ALA penetration through mouse skin and in vivo PpIX production in human skin. Photochem. Photobiol. Sci. 3, 263267.
  • 150
    Rhodes, L. E., M. M. Tsoukas, R. R. Anderson and N. Kollias (1997) Iontophoretic delivery of ALA provides a quantitative model for ALA pharmacokinetics and PpIX phototoxicity in human skin. J. Invest. Dermatol. 108, 8791.
  • 151
    Star, W. M., M. C. G. Aalders, A. Sac and H. J. C. M. Sterenborg (2002) Quantitative model calculation of the time-dependent protoporphyrin IX concentration in normal human epidermis after delivery of ALA by passive topical application or iontophoresis. Photochem. Photobiol. 75, 429432.
  • 152
    Lopez, R. F., M. V. L. B. Bentley, M. B. Delgado-Charro and R. H. Guy (2001) Iontophoretic delivery of 5-aminolevulinic acid (ALA): effect of pH. Pharm. Res. 18, 311315.
  • 153
    Gerscher, S., J. P. Connelly, G. M. J. Van Henegouwen, A. J. MacRobert, P. Watt and L. E. Rhodes (2001) A quantitative assessment of protoporphyrin IX metabolism and phototoxicity in human skin following dose-controlled delivery of the prodrugs 5-aminolaevulinic acid and 5-aminolaevelunic acid-n-pentlyester. Br. J. Dermatol. 144, 983990.
  • 154
    Lopez, R. F., M. V. L. B. Bentley, M. B. Delgado-Charro, H. Van den Bergh, N. Lange and R. H. Guy (2003) Enhanced delivery of 5-aminolevulinic acid esters by iontophoresis in vitro. Photochem. Photobiol. 77, 304308.
  • 155
    Gerscher, S., J. P. Connelly, J. Griffiths, S. B. Brown, A. J. MacRobert, G. Wong and L. E. Rhodes (2000) Comparison of the pharmacokinetics and phototoxicity of protoporphyrin IX metabolized from 5-aminolevulinic acid and two derivatives in human skin in vivo. Photochem. Photobiol. 72, 569574.
  • 156
    Curnow, A., B. W. McIlroy, M. J. Postle-Hacon, J. B. Porter, A. J. MacRobert and S. G. Bown (1998) Enhancement of 5-aminolevulinic acid-induced photodynamic therapy in normal rat colon using hydroxypyridinone iron-chelating agents. Br. J. Cancer 78, 12781282.
  • 157
    Hanania, J. and Z. Malik (1992) The effect of EDTA and serum on endogenous porphyrin accumulation and photodynamic sensitization of human K562 leukemic cells. Cancer Lett. 65, 127131.
  • 158
    Shevchuk, I., V. Chekulayev, J. Moan and K. Berg (1996) Effects of the inhibitors of energy metabolism, Ionidamine and levamisole, on 5-aminolevulinic acid-induced photochemotherapy. Int. J. Cancer 67, 791799.
  • 159
    Wike-Hooley, J. L., J. Haveman and H. S. Reinhold (1984) The relevance of tumour pH to the treatment of malignant disease. Radiother. Oncol. 2, 343366.
  • 160
    Wyld, L., M. W. R. Reed and N. J. Brown (1998) The influence of hypoxia and pH on aminolevulinic acid-induced photodynamic therapy in bladder cancer cells in vitro. Br. J. Cancer 77, 16211627.
  • 161
    Bech, O., K. Berg and J. Moan (1997) The pH dependency of protoporphyrin IX formation in cells incubated with 5-aminolevulinic acid. Cancer Lett. 113, 2529.
  • 162
    Piot, B., N. Rousset, P. Lenz, S. Eleout, J. Carre, V. Vonarx, L. Bourre and T. Patrice (2001) Enhancement of 5-aminolevulinic acid-photodynamic therapy in vivo by decreasing tumour pH with glucose and amiloride. Laryngoscope 111, 22052213.
  • 163
    Musgrove, E., M. Seaman and D. Hedley (1987) Relationship between cytoplasmic pH and proliferation during exponential growth and cellular quiescence. Exp. Cell Res. 172, 6575.
  • 164
    Schick, E., R. Kaufmann, A. Ruck, A. Hainzl and W.-H. Boehncke (1995) On the effectiveness of photodynamic therapy. Acta Dermatol. Venereol. 75, 276279.
  • 165
    Gfatter, R., P. Hackl and F. Braun (1997) Effects of soap and detergents on skin surface pH, stratum corneum hydration and fat content in infants. Dermatol. 195, 258262.
  • 166
    Van der Veen, N., H. L. L. M. Van Leengoed and W. M. Star (1994) In vivo fluorescence kinetics and photodynamic therapy using 5-aminolevulinic acid-induced porphyrin: increased damage after multiple irradiations. Br. J. Cancer 70, 867872.
  • 167
    de Bruijn, H. S., N. Van der Veen, D. J. Robinson and W. M. Star (1999) Improvement of systemic 5-aminolevulinic acid-based photodynamic therapy in vivo using light fractionation with a 75-minute interval. Cancer Res. 59, 901904.
  • 168
    Juzenas, P., R. Sorensen, V. Iani and J. Moan (1999) Uptake of topically applied 5-aminolevulinic acid and production of protoporphyrin IX in normal mouse skin: dependence on skin temperature. Photochem. Photobiol. 69, 478481.
  • 169
    Gibson, S. L., D. J. Cupriks, and J. J. Havens (1998) A regulatory role for porphobilinogen deaminase (PBGD) in delta-aminolaevulinic acid (delta-ALA)-induced photosensitization Br. J. Cancer 77, 235243.
  • 170
    Von Beckerath, M., P. Juzenas, L. W. Ma, V. Iani, L. Lofgren and J. Moan (2001) The influence of UV exposure on 5-aminolevulinic acid-induced protoporphyrin IX production in skin. Photochem. Photobiol. 74, 825828.
  • 171
    Bottomley, S. and U. Muller-Eberhard (1988) Pathophysiology of heme synthesis. Sem. Heme Synth. 25, 282302.
  • 172
    Krems, I. and P. E. Spoerri (1947) The pyrazines. Chem. Rev. 40, 290358.
  • 173
    Franck, B. and H. Stratmann (1981) Condensation products of the porphyrin precursor 5-aminolevulinic acid. Heterocycles 15, 919923.
  • 174
    Butler, A. R. and S. George (1992) The nonenzymatic cyclic dimerisation of 5-aminolevulinic acid. Tetrahedron 48, 78797886.
  • 175
    Granick, S. and D. Mauzerall (1957) Porphyrin biosynthesis in erythrocytes ii: enzymes converting 5-aminolevulinic acid to coproporphyrinogen. J. Biol. Chem. 232, 11191140.
  • 176
    Jaffe, E. K. and J. S. Rajagopalan (1990) Nuclear magnetic resonance studies of 5- aminolevulinate demonstrate multiple forms in aqueous solution. Bioorg. Chem. 18, 381394.
  • 177
    Dalton, J. T., D. Zhou, A. Mukherjee, D. Young, E. A. Tolley, A. L. Golub and M. C. Meyer (1999) Pharmacokinetics of aminolevulinic acid after intravesical administration to dogs. Pharm. Res. 16, 288295.
  • 178
    Gadmar, O. B., J. Moan, E. Scheie, L. W. Ma and Q. Peng (2002) The stability of 5-aminolevulinic acid in solution. J. Photochem. Photobiol. B: Biol. 67, 187193.
  • 179
    Bunke, A., O. Zerbe, H. Schmid, G. Burmeister, H. P. Merkle and B. Gander (2000) Degradation mechanism and stability of 5-aminolevulinic acid. J. Pharm. Sci. 89, 13351341.
  • 180
    de Blois, A. W., R. J. E. Grouls, E. W. Ackerman and W. J. A. Wijdeven (2002) Development of a stable solution of 5-aminolevulinic acid for intracutaneous injection in photodynamic therapy. Lasers Med. Sci. 17, 208215.
  • 181
    Bunke, A., H. Schmid, G. Burmeister, H. P. Merkle and B. Gander (2000) Validation of a capillary electrophoresis method for determination of 5-aminolevulinic acid and degradation products. J. Chromatogr. A 883, 285290.
  • 182
    Novo Rodriguez, M., G. Huttmann and H. Diddens (1995) Chemical instability of 5-aminolevulinic acid (ala) in aqueous solution. SPIE 2371, 204209.
  • 183
    Elfsson, B., I. Wallin, S. Eksborg, K. Rudaeus, A. M. Ros and H. Ehrsson (1998) Stability of 5-aminolevulinic acid in aqueous solution. Eur. J. Pharm. Sci. 7, 8791.
  • 184
    International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (2003) ICH-Topic Q6A: Test Procedures and Acceptance Criteria for New Drug Products: Chemical Substances. Geneva, Switzerland .
  • 185
    International Conference on Harmonisation of Technical Require ments for Registration of Pharmaceuticals for Human Use (2003) ICH-Topic Q6B: Test Procedures and Acceptance Criteria for Biotechnological/Biological Products. Geneva, Switzerland .
  • 186
    Cairns, D. (2000) Essentials of Pharmaceutical Chemistry. Pharma ceutical Press, London .
  • 187
    Martin, A., J. Swarbrick and A. Cammarata (1983) Physical Pharmacy. Lea & Febiger, Philadelphia .
  • 188
    Hopper, C. (1996) The role of photodynamic therapy in the management of oral cancer and precancer. Eur. J. Cancer 32B, 7172.
  • 189
    Kurwa, H. A., R. J. Barlow and S. Neill (2000) Single-episode photodynamic therapy and vulval intraepithelial neoplasia Type III resistant to conventional therapy. Br. J. Dermatol. 143, 10401042.
  • 190
    Dougherty, T. J. (2002) An update on photodynamic therapy applications. J. Clin. Laser Med. Surg. 20, 37.
  • 191
    Gudgin Dickson, E. F., R. L. Goyan and R. H. Pottier (2002) New directions in photodynamic therapy. Cell. Mol. Biol. 48, 939954.
  • 192
    Morton, C. A., S. B. Brown, S. Collins, S. Ibbotson, H. Jenkinson, H. Kurwa, K. Langmack, K. McKenna, H. Moseley, A. D. Pearse, M. Stringer, D. K. Taylor, G. Wong and L. E. Rhodes (2002) Guidelines for topical photodynamic therapy: a report of a workshop of the British Photodermatology Group. Br. J. Dermatol. 146, 552567.
  • 193
    Markham, T. and P. Collins (2001) Topical 5-aminolevulinic acid photodynamic therapy for extensive scalp actinic keratoses. Br. J. Dermatol. 145, 502504.
  • 194
    Monk, B. J., C. Brewer, K. Van Nostrand, M. W. Berns, J. L. McCullough, Y. Tadir and A. Manetta (1997) Photodynamic therapy using topically applied dihematoporphyrin ether in the treatment of cervical intraepithelial neoplasia. Gyn. Oncol. 64, 7075.
  • 195
    Hillemanns, P., M. Korell, M. Schmitt-Sody, R. Baumgartner, W. Beyer, R. Kimming, M. Untch and H. Hepp (1999) Photodynamic therapy in women with cervical intraepithelial neoplasia using topically applied 5-aminolevulinic acid. Int. J. Cancer 81, 3438.
  • 196
    Hillemanns, P., M. Untch, C. Dannecker, R. Baumgartner, H. Stepp, J. Diebold, H. Weingandt, F. Prove and M. Korell (2000) Photodynamic therapy of vulvar intraepithelial neoplasia using 5- aminolevulinic acid. Int. J. Cancer 85, 649653.
  • 197
    Zawislak, A., J. H. Price, P. A. McCarron, R. F. Donnelly and A. D. Woolfson (2002) Lighting up tumours—topical treatment of superficial lesions using 5-aminolevulinic acid based photodynamic therapy. N. Irl. Med. Rev. 4, 2628.
  • 198
    Hebeda, K. M., M. T. Huizing, P. A. Brouwer, F. W. Van der Meulen, H. J. Hulsebosch, J. H. Reiss, P. Oosting, C. H. N. Veenhof and P. J. M. Bakker (1995) Photodynamic therapy in AIDS-related cutaneous Kaposi's sarcoma. J. Acq. Imm. Def. Synd. Hum. Retrovirol. 10, 6170.
  • 199
    Donnelly, R. F., P. A. McCarron, A. D. Woolfson and A. Zawislak (2002) 5-Aminolevulinic acid for photodynamic therapy of vulval intraepithelial neoplasia. assay development and release from a proprietary formulation. J. Pharm. Pharmacol. 54, S16.
  • 200
    Porphin® Product Information Sheet. (1996) Crawford Pharmaceuticals, Milton Keynes, UK .
  • 201
    Chang, S. C., A. J. MacRobert and S. G. Bown (1996) Photodynamic therapy of rat urinary bladder with intravesical instillation of 5-aminolevulinic acid: light diffusion and histological changes. J. Urol. 155, 17491753.
  • 202
    Bretschko, E., R. M. Szeimies, M. Landthaler and G. Lee (1996) Topical 5-aminolevulinic acid for photodynamic therapy of basal cell carcinoma. evaluation of stratum corneum permeability in vitro. J. Cont. Rel. 42, 203208.
  • 203
    Moon, S. H. and M. D. Foster (2002) Influence of humidity on surface behaviour of pressure sensitive adhesives studied using scanning probe microscopy. Langmuir 18, 81088115.
  • 204
    Pons, P., P. Roald, B. Nestor, G. Rafael and A. Agustin (2001) Transdermic patches for photodynamic therapy of superficial lesions. Proceedings of the 29th Annual Meeting of the American Society of Photobiology, Chicago , IL .
  • 205
    McCarron, P. A., R. F. Donnelly, A. D. Woolfson and A. Zawislak (2003) Photodynamic therapy of vulval intraepithelial neoplasia using bioadhesive patch-based delivery of aminolevulinic acid. Drug Del. Sys. Sci. 3, 5964.
  • 206
    McCarron, P. A., R. F. Donnelly, B. F. Gilmore, A. D. Woolfson, R. McClelland, A. Zawislak and J. H. Price (2004) Phototoxicity of 5-aminolevulinic acid in the HeLa cell line as an indicative measure of photodynamic effect after topical administration to gynaecological lesions of intraepithelial form. Pharm. Res. 21, 18731881.
  • 207
    McCarron, P. A., R. F. Donnelly, A. D. Woolfson, A. Zawislak, J. H. Price and P. Maxwell (2004) Photodynamic treatment of lichen sclerosus and squamous hyperplasia using sustained topical delivery of aminolevulinic acid from a novel bioadhesive. Br. J. Dermatol. 151, (Suppl. 68), 105106.
  • 208
    Manivasager, V., P. W. S. Heng, J. Hao, W. Zheng, K. C. Soom and M. Olivo (2002) Macro-microscopic fluorescence imaging of human NPC xenografts in a murine model using topical vs intravenous administration of 5-aminolevulinic acid. Int. J. Oncol. 21, 10031007.
  • 209
    Manivasager, V., P. W. S. Heng, J. Hao, W. Zheng, K. C. Soom and M. Olivo (2003) A study of 5-aminolevulinic acid and its methyl ester used in in vitro and in vivo systems of human bladder Cancer. Int. J. Oncol. 22, 313318.
  • 210
    Turchiello, R. F., F. C. B. Vena, P. Maillard, C. S. Souza, M. V. L. B. Bentley and A. C. Tedesco (2003) Cubic phase gel as a drug delivery system for topical application of 5-ALA, its ester derivatives and m-THPC in photodynamic therapy. J. Photochem. Photobiol. B: Biol. 70, 16.
  • 211
    Tsai, J. C., C. P. Chiang, H. M. Chen, S. B. Huang, C. W. Wang, M. I. Lee, Y. C. Hsu, C. T. Chen and T. Tsai (2004) Photodynamic therapy of oral dysplasia with topical 5-aminolevulinic acid and light-emitting diode array. Lasers Surg. Med. 34, 1824.
  • 212
    Bourre, L., S. Thibaut, A. Briffaud, Y. Lajat and T. Patrice (2002) Potential efficacy of a 5-aminolevulinic acid thermosetting gel formulation for use in photodynamic therapy of lesions of the gastrointestinal tract. Pharmacol. Res. 45, 159165.
  • 213
    Pierre, M. B. R., A. C. Tedesco, J. M. Marchetti and M. V. L. B. Bentley (2001) Stratum corneum lipids liposomes for the topical delivery of 5-aminolevulinic acid in photodynamic therapy of skin cancer: preparation and in vitro permeation study. BMC Dermatol. 1, 14711476.
  • 214
    Casas, A., C. Perotti, M. Saccoliti, H. Fukuda A. M. Del and C. Batlle (2002) ALA and ALA hexyl ester in free and liposomal formulations for the photosensitisation of tumour organ cultures. Br. J. Cancer 86, 837842.
  • 215
    DUSA Pharmaceuticals (2001) Available at: http://www.dusapharma.com. Accessed 25 November 2001.