Imaging of Photodynamically Generated Singlet Oxygen Luminescence In Vivo


  • Posted on the website on 2 May 2005

*To whom correspondence should be addressed: Division of Biophysics and Bioimaging, Ontario Cancer Institute, 610 University Avenue, Toronto, ON M5G 2M9, Canada. Fax: 416-946-6529; e-mail:


We describe a novel scanning-laser system for imaging type-II photodynamically generated singlet oxygen (1O2[1Δg]) luminescence and demonstrate it in vivo in an intradermal tumor model in mice. We verify the strong oxygen-dependence of the signal and show that the images are near the practical resolution limit.